GPR1

GPR1
Identifiers
Aliases	GPR1
External IDs	MGI: 2385324 HomoloGene: 21094 GeneCards: GPR1
Gene ontology Molecular function • neuropeptide binding • signal transducer activity • protein binding • G-protein coupled receptor activity Cellular component • plasma membrane • membrane • integral component of membrane • integral component of plasma membrane • neuron projection Biological process • chemical synaptic transmission • neuropeptide signaling pathway • G-protein coupled receptor signaling pathway • signal transduction • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2825	241070
Ensembl	ENSG00000183671	ENSMUSG00000046856
UniProt	P46091	Q8K087
RefSeq (mRNA)	NM_001098199 NM_001261452 NM_001261453 NM_001261454 NM_001261455 NM_005279	NM_146250
RefSeq (protein)	NP_001091669 NP_001248381 NP_001248382 NP_001248383 NP_001248384 NP_005270	NP_666362.1
Location (UCSC)	Chr 2: 206.18 – 206.22 Mb	Chr 1: 63.18 – 63.21 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene.

GPR1 is a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin. Other receptors for chemerin include CMKLR1 and CCRL2.

Further reading

• Shimizu N, Soda Y, Kanbe K, et al. (1999). "An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived Cells". J. Virol. 73 (6): 5231–9. PMC 112576. PMID 10233994. 
• Tokizawa S, Shimizu N, Hui-Yu L, et al. (2000). "Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor". Kidney Int. 58 (2): 607–17. doi:10.1046/j.1523-1755.2000.00207.x. PMID 10916084. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes". Exp. Cell Res. 287 (2): 272–81. doi:10.1016/S0014-4827(03)00061-2. PMID 12837283. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Jinno-Oue A, Shimizu N, Soda Y, et al. (2005). "The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1". J. Biol. Chem. 280 (35): 30924–34. doi:10.1074/jbc.M500195200. PMID 15919664. 
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.