Neuropeptide Y receptor Y2

NPY2R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IK3
Identifiers
Aliases	NPY2R, NPY2-R, Neuropeptide Y receptor Y2
External IDs	MGI: 108418 HomoloGene: 701 GeneCards: NPY2R
Targeted by Drug
BIIE0246
Gene ontology Molecular function • neuropeptide Y receptor activity • G-protein coupled receptor activity • calcium channel regulator activity • signal transducer activity • protein binding • peptide YY receptor activity • receptor activity Cellular component • integral component of membrane • nonmotile primary cilium • membrane • plasma membrane • integral component of plasma membrane • intracellular Biological process • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • regulation of sensory perception of pain • locomotory behavior • positive regulation of cytosolic calcium ion concentration • positive regulation of peptide secretion • outflow tract morphogenesis • cardiac left ventricle morphogenesis • negative regulation of neurological system process • negative regulation of synaptic transmission • behavioral fear response • negative regulation of excitatory postsynaptic potential • secretion • positive regulation of circadian sleep/wake cycle, non-REM sleep • cell surface receptor signaling pathway • positive regulation of dopamine secretion • negative regulation of secretion • feeding behavior • negative regulation of feeding behavior • nitric oxide mediated signal transduction • negative regulation of cAMP biosynthetic process • neuropeptide signaling pathway • positive regulation of smooth muscle contraction • negative regulation of synaptic transmission, glutamatergic • signal transduction • positive regulation of cell-substrate adhesion • aging • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4887	18167
Ensembl	ENSG00000185149	ENSMUSG00000028004
UniProt	P49146	P97295
RefSeq (mRNA)	NM_000910	NM_001205099 NM_008731
RefSeq (protein)	NP_000901.1	NP_032757.2
Location (UCSC)	Chr 4: 155.21 – 155.22 Mb	Chr 3: 82.54 – 82.55 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Neuropeptide Y receptor type 2 (Y2R) is a protein that in humans is encoded by the NPY2R gene.

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
• 2-Thiouridine 5'-triphosphate (CAS# 35763-29-2)
• Peptide YY
• Peptide YY 3-36 fragment

Antagonists

• BIIE-0246 (CAS# 246146-55-4)
• JNJ 5207787 (CAS# 683746-68-1)
• SF 11 (CAS# 443292-81-7)

See also

• Neuropeptide Y receptor

External links

• "Neuropeptide Y Receptors: Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Wan CP, Lau BH (Feb 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (Jul 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422. 
• Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL (Nov 1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". The Journal of Biological Chemistry. 270 (45): 26758–61. doi:10.1074/jbc.270.45.26758. PMID 7592910. 
• Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K (Mar 1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". The Journal of Biological Chemistry. 269 (11): 8226–33. PMID 8132547. 
• Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA (Feb 1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor". Molecular Pharmacology. 49 (2): 224–8. PMID 8632753. 
• Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460. 
• Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA (Dec 1996). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics. 38 (3): 392–8. doi:10.1006/geno.1996.0642. PMID 8975716. 
• Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (Jul 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
• Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL (Sep 1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience. 86 (1): 167–78. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752. 
• Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M (Jul 2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Molecular Pharmacology. 60 (1): 124–34. PMID 11408607. 
• Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964. 
• Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM (Jun 2003). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". British Journal of Pharmacology. 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMC 1573894. PMID 12813010. 
• Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS (Sep 2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes. 53 (9): 2461–6. doi:10.2337/diabetes.53.9.2461. PMID 15331560.