ZEB1

ZEB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E19
Identifiers
Aliases	ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDs	MGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1
Gene ontology Molecular function • DNA binding • transcription corepressor activity • transcription coactivator activity • zinc ion binding • transcription factor binding • chromatin binding • metal ion binding • protein binding • nucleic acid binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • E-box binding Cellular component • cytoplasm • transcription factor complex • nucleoplasm • nucleus Biological process • pattern specification process • embryonic skeletal system morphogenesis • regulation of smooth muscle cell differentiation • animal organ development • cell differentiation • semicircular canal morphogenesis • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • nervous system development • regulation of transforming growth factor beta receptor signaling pathway • regulation of T cell differentiation in thymus • central nervous system development • cartilage development • regulation of mesenchymal cell proliferation • embryonic camera-type eye morphogenesis • cochlea morphogenesis • immune response • embryonic morphogenesis • cellular response to amino acid stimulus • cell proliferation • negative regulation of epithelial cell differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • negative regulation of transcription, DNA-templated • positive regulation of neuron differentiation • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6935	21417
Ensembl	ENSG00000148516	ENSMUSG00000024238
UniProt	P37275	Q64318
RefSeq (mRNA)	NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096 NM_030751 NM_001323638 NM_001323641 NM_001323642 NM_001323643 NM_001323644 NM_001323645 NM_001323646 NM_001323647 NM_001323648 NM_001323649 NM_001323650 NM_001323651 NM_001323652 NM_001323653 NM_001323654 NM_001323655 NM_001323656 NM_001323657 NM_001323658 NM_001323659 NM_001323660 NM_001323661 NM_001323662 NM_001323663 NM_001323664 NM_001323665 NM_001323666 NM_001323671 NM_001323672 NM_001323673 NM_001323674 NM_001323675 NM_001323676 NM_001323677 NM_001323678	NM_011546
RefSeq (protein)	NP_001121600.1 NP_001167564.1 NP_001167565.1 NP_001167566.1 NP_001167567.1 NP_110378.3	NP_035676.1
Location (UCSC)	Chr 10: 31.32 – 31.53 Mb	Chr 18: 5.59 – 5.78 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain. The structure of the homeodomain shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.

Further reading

• Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.". Mol. Cell. Biol. 14 (10): 6773–88. PMC 359208. PMID 7935395. 
• Watanabe Y, Kawakami K, Hirayama Y, Nagano K (1994). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene.". J. Biochem. 114 (6): 849–55. PMID 8138542. 
• Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (1998). "Involvement of negative co-factor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.". Mol. Cell. Biol. 18 (1): 10–8. doi:10.1128/mcb.18.1.10. PMC 121442. PMID 9418848. 
• Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649. 
• Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. doi:10.1073/pnas.96.12.6683. PMC 21975. PMID 10359772. 
• Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (2001). "Tip60 is a cell-type-specific transcriptional regulator.". J. Biochem. 129 (4): 635–41. doi:10.1093/oxfordjournals.jbchem.a002901. PMID 11275565. 
• Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S (2002). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology.". J. Bone Miner. Res. 16 (12): 2192–204. doi:10.1359/jbmr.2001.16.12.2192. PMID 11760832. 
• Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028. 
• Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J (2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.". J. Biol. Chem. 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443. 
• Costantino ME, Stearman RP, Smith GE, Darling DS (2002). "Cell-specific phosphorylation of Zfhep transcription factor.". Biochem. Biophys. Res. Commun. 296 (2): 368–73. doi:10.1016/S0006-291X(02)00880-X. PMID 12163027. 
• Postigo AA (2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.". EMBO J. 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMC 155983. PMID 12743038. 
• Postigo AA, Depp JL, Taylor JJ, Kroll KL (2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.". EMBO J. 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMC 155984. PMID 12743039. 
• Dillner NB, Sanders MM (2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades.". DNA Cell Biol. 23 (1): 25–34. doi:10.1089/104454904322745907. PMID 14965470. 
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
• Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE (2005). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.". Am. J. Med. Genet. A. 130 (4): 372–7. doi:10.1002/ajmg.a.30267. PMC 1249494. PMID 15384081. 
• Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R (2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.". Oncogene. 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322. 

External links

• FactorBook ZEB1