ZNF300

ZNF300
Identifiers
Aliases	ZNF300
External IDs	HomoloGene: 56531 GeneCards: ZNF300
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • protein binding • metal ion binding • nucleic acid binding Cellular component • intracellular • nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	91975	n/a
Ensembl	ENSG00000145908	n/a
UniProt	Q96RE9	n/a
RefSeq (mRNA)	NM_001172831 NM_001172832 NM_052860	n/a
RefSeq (protein)	NP_001166302 NP_001166303 NP_443092	n/a
Location (UCSC)	Chr 5: 150.89 – 150.9 Mb	n/a
PubMed search		n/a
Wikidata
View/Edit Human

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene. The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

Clinical relevance

It is associated with Crohn's disease.

Further reading

• Feng T, Zhu X (2010). "Genome-wide searching of rare genetic variants in WTCCC data.". Hum. Genet. 128 (3): 269–80. doi:10.1007/s00439-010-0849-9. PMC 2922446. PMID 20549515. 
• Qiu H, Xue L, Gao L, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein.". Cell. Mol. Biol. Lett. 13 (3): 391–403. doi:10.2478/s11658-008-0005-x. PMID 18350257. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Xu JH, Wang T, Wang XG, et al. (2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60.". Leuk. Res. 34 (12): 1636–46. doi:10.1016/j.leukres.2010.04.009. PMID 20471086. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Xue L, Qiu H, Ma J, et al. (2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site.". Cell. Mol. Biol. Lett. 15 (4): 530–40. doi:10.2478/s11658-010-0025-1. PMID 20585888. 
• Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer.". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Cao Y, Li JX, Ji CN, et al. (2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis.". DNA Seq. 18 (4): 312–5. doi:10.1080/10425170701243393. PMID 17541838. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
• "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.". Nature. 447 (7145): 661–78. 2007. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.