PHF1

PHF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5P, 2M0O, 4HCZ
Identifiers
Aliases	PHF1, MTF2L2, PCL1, PHF2, TDRD19C, hPHD finger protein 1
External IDs	MGI: 98647 HomoloGene: 7567 GeneCards: PHF1
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • zinc ion binding • metal ion binding • methylated histone binding • protein binding • chromatin binding Cellular component • cytoplasm • site of double-strand break • ESC/E(Z) complex • nucleoplasm • microtubule organizing center • cytoskeleton • nucleus Biological process • negative regulation of histone H3-K27 methylation • regulation of transcription, DNA-templated • transcription, DNA-templated • cellular response to DNA damage stimulus • regulation of histone methylation • negative regulation of gene expression, epigenetic • positive regulation of histone H3-K27 methylation • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5252	21652
Ensembl	n/a	ENSMUSG00000024193
UniProt	O43189	Q9Z1B8
RefSeq (mRNA)	NM_002636 NM_024165	NM_009343 NM_001302397
RefSeq (protein)	NP_002627 NP_077084	NP_033369.2
Location (UCSC)	Chr 6: 33.41 – 33.42 Mb	Chr 17: 26.93 – 26.94 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.

Further reading

• Cao R, Wang H, He J, et al. (2008). "Role of hPHF1 in H3K27 Methylation and Hox Gene Silencing". Mol. Cell. Biol. 28 (5): 1862–72. doi:10.1128/MCB.01589-07. PMC 2258785. PMID 18086877. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• O'Connell S, Wang L, Robert S, et al. (2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein". J. Biol. Chem. 276 (46): 43065–73. doi:10.1074/jbc.M104294200. PMID 11571280. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 

External links

• PHF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.