ILF2

ILF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AT7, 4AT8, 4AT9, 4ATB
Identifiers
Aliases	ILF2, NF45, PRO3063, interleukin enhancer binding factor 2
External IDs	MGI: 1915031 HomoloGene: 26894 GeneCards: ILF2
Gene ontology Molecular function • transferase activity • DNA binding • double-stranded RNA binding • poly(A) RNA binding • protein binding • ATP binding • RNA binding Cellular component • cytoplasm • intracellular ribonucleoprotein complex • nucleolus • membrane • nucleus • nucleoplasm Biological process • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • immune response • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3608	67781
Ensembl	ENSG00000143621	ENSMUSG00000001016
UniProt	Q12905	Q9CXY6
RefSeq (mRNA)	NM_004515 NM_001267809	NM_026374
RefSeq (protein)	NP_001254738 NP_004506	NP_080650.1
Location (UCSC)	Chr 1: 153.66 – 153.67 Mb	Chr 3: 90.48 – 90.49 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.

Function

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.

Interactions

ILF2 has been shown to interact with CDC5L and DNA-PKcs.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Marcoulatos P, Koussidis G, Mamuris Z, Velissariou V, Vamvakopoulos NC (Dec 1996). "Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates". Journal of Interferon & Cytokine Research. 16 (12): 1035–8. doi:10.1089/jir.1996.16.1035. PMID 8974006. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (Jan 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054. 
• Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry. 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367. 
• Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (Dec 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923. 
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529. 
• Parker LM, Fierro-Monti I, Mathews MB (Aug 2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". The Journal of Biological Chemistry. 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540. 
• Reichman TW, Muñiz LC, Mathews MB (Jan 2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Molecular and Cellular Biology. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746. 
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. 
• Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM (Mar 2002). "Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA". Archives of Virology. 147 (3): 471–91. doi:10.1007/s007050200001. PMID 11958450. 
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849. 
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (Nov 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993. 
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
• Zhao G, Shi L, Qiu D, Hu H, Kao PN (May 2005). "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function". Experimental Cell Research. 305 (2): 312–23. doi:10.1016/j.yexcr.2004.12.030. PMID 15817156. 
• Nie Y, Ding L, Kao PN, Braun R, Yang JH (Aug 2005). "ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing". Molecular and Cellular Biology. 25 (16): 6956–63. doi:10.1128/MCB.25.16.6956-6963.2005. PMC 1190226. PMID 16055709. 
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

External links

• ILF2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.