EGR3

EGR3
Identifiers
Aliases	EGR3, EGR-3, PILOT, early growth response 3
External IDs	MGI: 1306780 HomoloGene: 37923 GeneCards: EGR3
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • metal ion binding • DNA binding • nucleic acid binding Cellular component • nucleus Biological process • circadian rhythm • endothelial cell chemotaxis • cell migration involved in sprouting angiogenesis • muscle organ development • regulation of gamma-delta T cell differentiation • regulation of transcription, DNA-templated • positive regulation of endothelial cell proliferation • neuromuscular synaptic transmission • peripheral nervous system development • cellular response to fibroblast growth factor stimulus • negative regulation of apoptotic process • cellular response to vascular endothelial growth factor stimulus • positive regulation of T cell differentiation in thymus • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1960	13655
Ensembl	ENSG00000179388	ENSMUSG00000033730
UniProt	Q06889	P43300
RefSeq (mRNA)	NM_001199880 NM_001199881 NM_004430	NM_001289925 NM_001289927 NM_018781
RefSeq (protein)	NP_001186809.1 NP_001186810.1 NP_004421.2	NP_061251.1
Location (UCSC)	Chr 8: 22.69 – 22.69 Mb	Chr 14: 70.08 – 70.08 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Early growth response protein 3 is a protein that in humans is encoded by the EGR3 gene.

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.

Further reading

• Yamada K, Gerber DJ, Iwayama Y, et al. (2007). "Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 104 (8): 2815–2820. doi:10.1073/pnas.0610765104. PMC 1815264. PMID 17360599. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Yoo YG, Lee MO (2004). "Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor". J. Biol. Chem. 279 (35): 36242–36249. doi:10.1074/jbc.M401290200. PMID 15173177. 
• Inoue A, Omoto Y, Yamaguchi Y, et al. (2005). "Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells". J. Mol. Endocrinol. 32 (3): 649–661. doi:10.1677/jme.0.0320649. PMID 15171706. 
• Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–2007. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Tourtellotte WG, Milbrandt J (1998). "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3". Nat. Genet. 20 (1): 87–91. doi:10.1038/1757. PMID 9731539. 
• Morris ME, Viswanathan N, Kuhlman S, et al. (1998). "A screen for genes induced in the suprachiasmatic nucleus by light". Science. 279 (5356): 1544–1547. doi:10.1126/science.279.5356.1544. PMID 9488654. 
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549. 
• Mages HW, Stamminger T, Rilke O, et al. (1993). "Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells". Int. Immunol. 5 (1): 63–70. doi:10.1093/intimm/5.1.63. PMID 8443122. 

External links

• EGR3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.