O-774

O-774
Identifiers
	IUPAC name 7-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]-7-methyloctanenitrile;
PubChem (CID)	10833730
ChemSpider	9009030
Chemical and physical data
Formula	C25H35NO2
Molar mass	381.550 g/mol
3D model (Jmol)	Interactive image
	SMILES N#CCCCCCC(c2cc1OC([C@@H]3C/C=C(\C[C@H]3c1c(O)c2)C)(C)C)(C)C ;
	InChI InChI=1S/C25H35NO2/c1-17-10-11-20-19(14-17)23-21(27)15-18(16-22(23)28-25(20,4)5)24(2,3)12-8-6-7-9-13-26/h10,15-16,19-20,27H,6-9,11-12,14H2,1-5H3/t19-,20-/m1/s1 ; Key:RVTLXKSJDYALPU-WOJBJXKFSA-N ;
(what is this?)

O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a K_i of 0.6 nM at CB₁, and very potent cannabinoid effects in animal studies.^[1]^[2]

References[edit]

^ Singer M, et al. Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-Δ⁸-tetrahydrocannabinol. Journal of Medicinal Chemistry. 1998 Oct 22;41(22):4400-7. PMID 9784115
^ The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships. pp 6-9. Edited by Patricia H Reggio. Humana Press 2009. ISBN 978-1-58829-712-9

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[1] Singer M, et al. Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-Δ⁸-tetrahydrocannabinol. Journal of Medicinal Chemistry. 1998 Oct 22;41(22):4400-7. PMID 9784115

[2] The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships. pp 6-9. Edited by Patricia H Reggio. Humana Press 2009. ISBN 978-1-58829-712-9

[1]

[2]

O-774

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References[edit]

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