LASSBio-881

LASSBio-881
Identifiers
PubChem (CID)	16721055
ChemSpider	23293401
ChEMBL	CHEMBL234619
Chemical and physical data
Formula	C23H27N3O6
Molar mass	441.476 g/mol
3D model (Jmol)	Interactive image
	SMILES Oc1c(C(C)(C)C)cc(cc1C(C)(C)C)\C=N\NC(=O)c2cc3OCOc3cc2[N](=O)=O ;
	InChI InChI=1S/C23H27N3O6/c1-22(2,3)15-7-13(8-16(20(15)27)23(4,5)6)11-24-25-21(28)14-9-18-19(32-12-31-18)10-17(14)26(29)30/h7-11,27H,12H2,1-6H3,(H,25,28)/b24-11+ ; Key:XEYZVZBNMMRXSN-BHGWPJFGSA-N ;

LASSBio-881 is a drug which acts as both a non-selective partial agonist of the CB₁ and CB₂ cannabinoid receptors, and also as an antagonist of the TRPV1 receptor, as well as having antioxidant effects. It has potent anti-inflammatory and anti-hyperalgesic effects in animal studies.^[1]^[2]^[3]

References[edit]

^ Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra F, Bechara EJ, De-Paula FS, Goulart MO, Ferreira J, Calixto JB, Nunes MP, Bertho AL, Miranda AL, Barreiro EJ, Fraga CA. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors. Bioorganic and Medicinal Chemistry. 2007 Mar 15;15(6):2421-33. PMID 17275312
^ Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. British Journal of Pharmacology. 2010 Apr;159(8):1716-23. PMID 20401963
^ Santana P et al. NEUROACTIVE PROPERTIES OF THE MULTIFUNCTIONAL PROTOTYPE LASSBio-881: FOCUS ON THE CANNABINOID SYSTEM