Homochlorcyclizine

Homochlorcyclizine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none
Legal status
Legal status	℞ (Prescription only);
Identifiers
	IUPAC name 1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane;
CAS Number	848-53-3
PubChem (CID)	3627
ChemSpider	3501
UNII	N5MVC31W2N
KEGG	D08041
ChEMBL	CHEMBL151447
ECHA InfoCard	100.011.545
Chemical and physical data
Formula	C19H23ClN2
Molar mass	314.85 g/mol
3D model (Jmol)	Interactive image
	SMILES CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl ;

Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965.^[1] It is used in the treatment of allergies and other conditions. It also has some anticholinergic, antidopaminergic, and antiserotonergic properties.^[2]^[3]

References[edit]

^ "Homoclomin Tablets 10 mg" (PDF). Eisai Co. December 2007. Retrieved 2008-07-29. ^{[dead link]}
^ Haraguchi K, Ito K, Kotaki H, Sawada Y, Iga T (June 1997). "Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies". Drug Metabolism and Disposition: the Biological Fate of Chemicals. 25 (6): 675–84. PMID 9193868.
^ KIMURA ET, YOUNG PR, RICHARDS RK (1960). "Pharmacologic properties of N-p-chloro-benzhydryl-N'-methyl homopiperazine dihydrochloride (homochlorcyclizine; SA-97), a serotonin antagonist". The Journal of Allergy. 31: 237–47. PMID 14409112.

v t e Antihistamines (R06)

Aminoalkyl ethers	Bromazine (bromodiphenhydramine) Carbinoxamine Clemastine Chlorphenoxamine Diphenylpyraline Diphenhydramine Doxylamine Orphenadrine Phenyltoloxamine

Substituted alkylamines	Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Dimetindene Pheniramine Talastine

Substituted ethylenediamines	Chloropyramine Histapyrrodine Mepyramine Methapyrilene Tripelennamine (pyribenzamine)

Phenothiazine derivatives	Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine

Piperazine derivatives	Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Hydroxyzine Meclizine Oxatomide

Others for systemic use	Antazoline Azanator Azatadine Bamipine Cyproheptadine Deptropine Ebastine Emedastine Epinastine Ketotifen Latrepirdine Mebhydrolin Mizolastine Olopatadine Phenindamine Pimethixene Pyrrobutamine Quifenadine Rupatadine Triprolidine selective (Acrivastine Astemizole Azelastine Bilastine Desloratadine Fexofenadine Loratadine Terfenadine)

For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Isothipendyl Mepyramine Promethazine Thenalidine

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	℞ (Prescription only)
Identifiers
IUPAC name 1-[(4-chlorophenyl)-phenylmethyl]-4-methyl-1,4-diazepane
CAS Number	848-53-3
PubChem (CID)	3627
ChemSpider	3501
UNII	N5MVC31W2N^Y
KEGG	D08041
ChEMBL	CHEMBL151447
ECHA InfoCard	100.011.545
Chemical and physical data
Formula	C₁₉H₂₃ClN₂
Molar mass	314.85 g/mol
3D model (Jmol)	Interactive image
SMILES CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl