Tesaglitazar
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Systematic (IUPAC) name | |
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(2S)-2-Ethoxy-3-[4-[2-(4-methylsulfonyloxyphenyl)
ethoxy]phenyl]propanoic acid |
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Legal status | |
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Identifiers | |
CAS Number | 251565-85-2 |
ATC code | None |
PubChem | CID 208901 |
ChemSpider | 180999 |
UNII | 6734037O3L |
KEGG | D01274 |
ChEMBL | CHEMBL521632 |
Chemical data | |
Formula | C20H24O7S |
Molar mass | 408.46 g/mol |
3D model (Jmol) | Interactive image |
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Tesaglitazar (also known as AZ 242) is a dual peroxisome proliferator-activated receptor agonist with affinity to PPARα and PPARγ, proposed for the management of type 2 diabetes.[1]
The drug had completed several phase III clinical trials,[2] however in May, 2006 AstraZeneca announced that it had discontinued further development.[3]
References[edit]
- ^ Wilding JP, Gause-Nilsson I, Persson A (2007). "Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes". Diab Vasc Dis Res. 4 (3): 194–203. doi:10.3132/dvdr.2007.040. PMID 17907109.
- ^ "GALIDA (tesaglitazar) Clinical Trial Report Summaries". AstraZeneca. Retrieved 2008-03-17.[dead link]
- ^ "AstraZeneca Discontinues Development of GALIDA (tesaglitazar)". AstraZeneca. 2006-05-04. Retrieved 2012-07-23.
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