Imagabalin
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| Clinical data | |
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| ATC code | None |
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| Synonyms | PD-0332334; PD-332,334 |
| CAS Number | 610300-07-7 610300-00-0 (hydrochloride) |
| PubChem (CID) | 10236037 |
| ChemSpider | 8411525 |
| Chemical and physical data | |
| Formula | C9H19NO2 |
| Molar mass | 173.253 g/mol |
| 3D model (Jmol) | Interactive image |
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Imagabalin (INN, USAN; PD-332,334) is a drug which acts as a ligand for the α2δ subunit of the voltage-dependent calcium channel,[1] with some selectivity for the α2δ1 subunit over α2δ2.[2] Under development by Pfizer as a pharmaceutical medication, it has demonstrated preclinical efficacy of anxiolytic, analgesic, hypnotic, and anticonvulsant-like activity and is currently in phase III clinical trials for the treatment of generalized anxiety disorder.[2][3]
See also[edit]
References[edit]
- ^ Quintero JE, Pomerleau F, Huettl P, Johnson KW, Offord J, Gerhardt GA (July 2011). "Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology". Brain Research. 1401: 1–9. doi:10.1016/j.brainres.2011.05.025. PMID 21664606.
- ^ a b Larry Ereshefsky (2008). "Therapies in the Pipeline for Sleep Disorders: Focus on Novel Mechanisms and Disease Models" (PDF) (Press release). p. 11. Retrieved 2012-04-22.
- ^ "A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder". Retrieved 2012-04-22.
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