- published: 30 May 2018
- views: 84837
Regulatory T cell
The regulatory T cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells which modulate the immune system, maintain tolerance to self-antigens, and abrogate autoimmune disease. These cells generally suppress or downregulate induction and proliferation of effector T cells. Additional regulatory T cells known as Treg17 cells have recently been identified. Mouse models have suggested that modulation of Tregs can treat autoimmune disease and cancer, and facilitate organ transplantation.
Regulatory T cell populations
T regulatory cells are a component of the immune system that suppress immune responses of other cells. This is an important "self-check" built into the immune system to prevent excessive reactions. Regulatory T cells come in many forms with the most well-understood being those that express CD4, CD25, and Foxp3 (CD4+CD25+ regulatory T cells). These "Tregs" are different from helper T cells. Another regulatory T cell subset is Treg17 cells. Regulatory T cells are involved in shutting down immune responses after they have successfully eliminated invading organisms, and also in preventing autoimmunity.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Regulatory_T_cell
Podcasts:
-
Regulatory T cells
This video describes a detailed mechanism of action of regulatory T cell and also describes the genetic and epigenetic basis of Treg lineage specification.
published: 30 May 2018 -
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series Regulatory T cells, Tregs, immune tolerance, autoimmune diseases, Foxp3, thymus, peripheral immune tolerance, inflammation, anti-inflammatory cytokines, IL-10, TGF-beta, cytolysis, metabolic regulation, glucose, amino acids, dendritic cells, cancer, infections, immune-mediated damage, immune system, T cell subsets, natural Tregs, induced Tregs, immune response, immune-mediated diseases, immune homeostasis, self-reactive T cells, host tissues, immune modulation, immune suppression, immune regulation. WhatsApp group: https://chat.whatsapp.com/HTXQC1Ax2qfKYa3MrZiMeD Twitter: https://twitter.com/basic_series Facebook Group: https://www.facebook.com/groups/742235929758671 LinkedIn: https://www.linkedin.com/in/bas...
published: 30 Mar 2023 -
"Regulatory T cells for Immune Tolerance" by Dr. Shimon Sakaguchi
GLOBAL IMMUNOTALK 05-31-23
published: 01 Jun 2023 -
Regulatory T Cells - Wallchart
For our full list of products visit our website https://www.stemcell.com Follow STEMCELL Technologies on Twitter at https://twitter.com/STEMCELLTech Like STEMCELL Technologies on Facebook at https://www.facebook.com/stemcelltechnologies Subscribe to STEMCELL Technologies on YouTube at https://www.youtube.com/STEMCELLTechnologies
published: 07 May 2020 -
Brandl's Basics: T regulatory cells
This video explains the differentiation of T regulatory cells from CD4 positive T cells.
published: 04 May 2020 -
What does a regulatory T cell (Treg) do?
Learning objectives: Explain the anti-inflammatory cytokine producing role of the Treg cell. Describe the role of TGFβ in the Treg response and how this is a good example of a positive feedback signaling loop (common in immune responses). Explain the function of the IL-10 cytokine. Describe the cell lysis function of Treg cells. Explain how Tregs lyse other immune cells. Explain how this lysis function helps to avoid allergic and autoimmune responses. Describe how Tregs can reduce IL-2 signaling to limit immune cell proliferation. Explain the role of Tregs in preventing and causing disease.
published: 11 Apr 2021 -
T-Regulatory Cells In Tumor Progression And Therapy- Video Abstract ID 228887
Video abstract of review paper “T-Regulatory Cells In Tumor Progression And Therapy” published in the open access journal Cancer Management and Research by Verma A, Mathur R, Farooque A, et al. Abstract: Regulatory T cells (Tregs) are important members of the immune system regulating the host responses to infection and neoplasms. Tregs prevent autoimmune disorders by protecting the host-cells from an immune response, related to the peripheral tolerance. However, tumor cells use Tregs as a shield to protect themselves against anti-tumor immune response. Thus, Tregs are a hurdle in achieving the complete potential of anti-cancer therapies including immunotherapy. This has prompted the development of novel adjuvant therapies that obviate their negative effects thereby enhanci...
published: 23 Dec 2019 -
Treg Isolation Kits: Fast and Versatile Isolation of Human Regulatory T Cells
Get the highest purity Tregs directly from whole blood or PBMC in less time than other methods with STEMCELLs NEW Human Treg Isolation Kits - http://www.stemcell.com/en/Products/All-Products/Complete-Kit-for-Human-CD4CD127lowCD25-Regulatory-T-Cells.aspx
published: 23 Mar 2010 -
Chronic Inflammation - T Regulatory Cells (Lecture 4)
Chronic Inflammation - T Regulatory Cells (Lecture 4) An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function. Let's review this promising area of immunology. If you like this content and want more, I am doing a special lifetime membership offer. Click here: https://www.drbeen.com/yt-special-p/ Want to support this work?: Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true PayPal: https://paypal.me/mobeensyed?locale.x=en_US My substack: https://mobeensyedmd.substack.com/ #drbeen #koolbeens #chronicinflammation Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute pro...
published: 02 Jun 2022 -
Role of Regulatory T Cells in Tolerance: Implication in Human Diseases
Air date: Wednesday, March 24, 2010, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: Cells with regulatory function exist within all major T and NK cell subsets. Most attention has been focused on regulatory T (Tr) cells with a CD4+ phenotype: the naturally occurring Tr (nTreg) cells and the adaptive type 1 Tr (Tr1) cells. These two subsets of Tr cells, which are developmentally and functionally distinct, cooperate in suppressing activation of the immune system and thereby in maintaining immunological homeostasis and inducing tolerance to self and foreign antigens. nTreg cells arise from the thymus and their suppressor function is strictly dependent on high expression of the transcription factor FOXP3, whereas...
published: 15 Nov 2010
9:05
Regulatory T cells
- Order: Reorder
- Duration: 9:05
- Uploaded Date: 30 May 2018
- views: 84837
This video describes a detailed mechanism of action of regulatory T cell and also describes the genetic and epigenetic basis of Treg lineage specification.
This video describes a detailed mechanism of action of regulatory T cell and also describes the genetic and epigenetic basis of Treg lineage specification.
https://wn.com/Regulatory_T_Cells
This video describes a detailed mechanism of action of regulatory T cell and also describes the genetic and epigenetic basis of Treg lineage specification.
3:52
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
- Order: Reorder
- Duration: 3:52
- Uploaded Date: 30 Mar 2023
- views: 14283
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Regulatory T cells, Tregs, immune tolerance, autoimmune diseases, Foxp3, thymus...
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Regulatory T cells, Tregs, immune tolerance, autoimmune diseases, Foxp3, thymus, peripheral immune tolerance, inflammation, anti-inflammatory cytokines, IL-10, TGF-beta, cytolysis, metabolic regulation, glucose, amino acids, dendritic cells, cancer, infections, immune-mediated damage, immune system, T cell subsets, natural Tregs, induced Tregs, immune response, immune-mediated diseases, immune homeostasis, self-reactive T cells, host tissues, immune modulation, immune suppression, immune regulation.
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Disclaimer: The information provided is for educational purposes only. The content of this channel should not be considered as medical advice of any kind. Use this information at your own risk. We hold no responsibility for any issue, concerns, or damage arising from the content of the video. Under no circumstances this channel be responsible or liable in any way for any content, including but not limited to, any errors or omissions in the content, any loss, any damage of any kind incurred as a result of any content communicated in this video, whether by this channel or a third party. In no event shall this channel be liable for any special indirect or consequential damages of any damages whatsoever resulting from the content of the channel.
https://wn.com/Roles_Of_Regulatory_T_Cells_|_Immunology_|_Immune_System_|_Basic_Science_Series
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Regulatory T cells, Tregs, immune tolerance, autoimmune diseases, Foxp3, thymus, peripheral immune tolerance, inflammation, anti-inflammatory cytokines, IL-10, TGF-beta, cytolysis, metabolic regulation, glucose, amino acids, dendritic cells, cancer, infections, immune-mediated damage, immune system, T cell subsets, natural Tregs, induced Tregs, immune response, immune-mediated diseases, immune homeostasis, self-reactive T cells, host tissues, immune modulation, immune suppression, immune regulation.
WhatsApp group: https://chat.whatsapp.com/HTXQC1Ax2qfKYa3MrZiMeD
Twitter: https://twitter.com/basic_series
Facebook Group: https://www.facebook.com/groups/742235929758671
LinkedIn: https://www.linkedin.com/in/basic-science-series-a54439208/
Instagram: https://www.instagram.com/basic_science_series/
Support my work at https://www.patreon.com/user?u=37177596
Disclaimer: The information provided is for educational purposes only. The content of this channel should not be considered as medical advice of any kind. Use this information at your own risk. We hold no responsibility for any issue, concerns, or damage arising from the content of the video. Under no circumstances this channel be responsible or liable in any way for any content, including but not limited to, any errors or omissions in the content, any loss, any damage of any kind incurred as a result of any content communicated in this video, whether by this channel or a third party. In no event shall this channel be liable for any special indirect or consequential damages of any damages whatsoever resulting from the content of the channel.
- published: 30 Mar 2023
- views: 14283
1:16:42
"Regulatory T cells for Immune Tolerance" by Dr. Shimon Sakaguchi
- Order: Reorder
- Duration: 1:16:42
- Uploaded Date: 01 Jun 2023
- views: 5875
GLOBAL IMMUNOTALK 05-31-23
GLOBAL IMMUNOTALK 05-31-23
https://wn.com/Regulatory_T_Cells_For_Immune_Tolerance_By_Dr._Shimon_Sakaguchi
GLOBAL IMMUNOTALK 05-31-23
- published: 01 Jun 2023
- views: 5875
0:24
Regulatory T Cells - Wallchart
- Order: Reorder
- Duration: 0:24
- Uploaded Date: 07 May 2020
- views: 440
For our full list of products visit our website https://www.stemcell.com
Follow STEMCELL Technologies on Twitter at https://twitter.com/STEMCELLTech
Like ST...
For our full list of products visit our website https://www.stemcell.com
Follow STEMCELL Technologies on Twitter at https://twitter.com/STEMCELLTech
Like STEMCELL Technologies on Facebook at https://www.facebook.com/stemcelltechnologies
Subscribe to STEMCELL Technologies on YouTube at https://www.youtube.com/STEMCELLTechnologies
https://wn.com/Regulatory_T_Cells_Wallchart
For our full list of products visit our website https://www.stemcell.com
Follow STEMCELL Technologies on Twitter at https://twitter.com/STEMCELLTech
Like STEMCELL Technologies on Facebook at https://www.facebook.com/stemcelltechnologies
Subscribe to STEMCELL Technologies on YouTube at https://www.youtube.com/STEMCELLTechnologies
- published: 07 May 2020
- views: 440
4:08
Brandl's Basics: T regulatory cells
- Order: Reorder
- Duration: 4:08
- Uploaded Date: 04 May 2020
- views: 5886
This video explains the differentiation of T regulatory cells from CD4 positive T cells.
This video explains the differentiation of T regulatory cells from CD4 positive T cells.
https://wn.com/Brandl's_Basics_T_Regulatory_Cells
This video explains the differentiation of T regulatory cells from CD4 positive T cells.
- published: 04 May 2020
- views: 5886
9:59
What does a regulatory T cell (Treg) do?
- Order: Reorder
- Duration: 9:59
- Uploaded Date: 11 Apr 2021
- views: 6922
Learning objectives:
Explain the anti-inflammatory cytokine producing role of the Treg cell.
Describe the role of TGFβ in the Treg response and how this is a go...
Learning objectives:
Explain the anti-inflammatory cytokine producing role of the Treg cell.
Describe the role of TGFβ in the Treg response and how this is a good example of a positive feedback signaling loop (common in immune responses).
Explain the function of the IL-10 cytokine.
Describe the cell lysis function of Treg cells.
Explain how Tregs lyse other immune cells.
Explain how this lysis function helps to avoid allergic and autoimmune responses.
Describe how Tregs can reduce IL-2 signaling to limit immune cell proliferation.
Explain the role of Tregs in preventing and causing disease.
https://wn.com/What_Does_A_Regulatory_T_Cell_(Treg)_Do
Learning objectives:
Explain the anti-inflammatory cytokine producing role of the Treg cell.
Describe the role of TGFβ in the Treg response and how this is a good example of a positive feedback signaling loop (common in immune responses).
Explain the function of the IL-10 cytokine.
Describe the cell lysis function of Treg cells.
Explain how Tregs lyse other immune cells.
Explain how this lysis function helps to avoid allergic and autoimmune responses.
Describe how Tregs can reduce IL-2 signaling to limit immune cell proliferation.
Explain the role of Tregs in preventing and causing disease.
- published: 11 Apr 2021
- views: 6922
3:43
T-Regulatory Cells In Tumor Progression And Therapy- Video Abstract ID 228887
- Order: Reorder
- Duration: 3:43
- Uploaded Date: 23 Dec 2019
- views: 4187
Video abstract of review paper “T-Regulatory Cells In Tumor Progression And Therapy” published in the open access journal
Cancer Management and Re...
Video abstract of review paper “T-Regulatory Cells In Tumor Progression And Therapy” published in the open access journal
Cancer Management and Research by Verma A, Mathur R, Farooque A, et al.
Abstract: Regulatory T cells (Tregs) are important members of the immune system regulating the host responses to infection and neoplasms. Tregs prevent autoimmune disorders by protecting the host-cells from an immune response, related to the peripheral tolerance. However, tumor cells use Tregs as a shield to protect themselves against anti-tumor immune response. Thus, Tregs are a hurdle in achieving the complete potential of anti-cancer therapies including immunotherapy. This has prompted the development of novel adjuvant therapies that obviate their negative effects thereby enhancing the therapeutic efficacy. Our earlier studies have shown the efficacy of the glycolytic inhibitor, 2-deoxy-D-glucose (2-DG) by reducing the induced Tregs pool and enhance immune stimulation as well as local tumor control. These findings have suggested its potential for enhancing the efficacy of immunotherapy, besides radiotherapy and chemotherapy. This review provides a brief account of the current status of Tregs as a component of the immune-biology of tumors and various preclinical and clinical strategies pursued to obviate the limitations imposed by them in achieving therapeutic efficacy.
Read the full paper here: https://www.dovepress.com/t-regulatory-cells-in-tumor-progression-and-therapy-peer-reviewed-article-CMAR
https://wn.com/T_Regulatory_Cells_In_Tumor_Progression_And_Therapy_Video_Abstract_Id_228887
Video abstract of review paper “T-Regulatory Cells In Tumor Progression And Therapy” published in the open access journal
Cancer Management and Research by Verma A, Mathur R, Farooque A, et al.
Abstract: Regulatory T cells (Tregs) are important members of the immune system regulating the host responses to infection and neoplasms. Tregs prevent autoimmune disorders by protecting the host-cells from an immune response, related to the peripheral tolerance. However, tumor cells use Tregs as a shield to protect themselves against anti-tumor immune response. Thus, Tregs are a hurdle in achieving the complete potential of anti-cancer therapies including immunotherapy. This has prompted the development of novel adjuvant therapies that obviate their negative effects thereby enhancing the therapeutic efficacy. Our earlier studies have shown the efficacy of the glycolytic inhibitor, 2-deoxy-D-glucose (2-DG) by reducing the induced Tregs pool and enhance immune stimulation as well as local tumor control. These findings have suggested its potential for enhancing the efficacy of immunotherapy, besides radiotherapy and chemotherapy. This review provides a brief account of the current status of Tregs as a component of the immune-biology of tumors and various preclinical and clinical strategies pursued to obviate the limitations imposed by them in achieving therapeutic efficacy.
Read the full paper here: https://www.dovepress.com/t-regulatory-cells-in-tumor-progression-and-therapy-peer-reviewed-article-CMAR
- published: 23 Dec 2019
- views: 4187
1:32
Treg Isolation Kits: Fast and Versatile Isolation of Human Regulatory T Cells
- Order: Reorder
- Duration: 1:32
- Uploaded Date: 23 Mar 2010
- views: 3632
Get the highest purity Tregs directly from whole blood or PBMC in less time than other methods with STEMCELLs NEW Human Treg Isolation Kits - http://www.stemcel...
Get the highest purity Tregs directly from whole blood or PBMC in less time than other methods with STEMCELLs NEW Human Treg Isolation Kits - http://www.stemcell.com/en/Products/All-Products/Complete-Kit-for-Human-CD4CD127lowCD25-Regulatory-T-Cells.aspx
https://wn.com/Treg_Isolation_Kits_Fast_And_Versatile_Isolation_Of_Human_Regulatory_T_Cells
Get the highest purity Tregs directly from whole blood or PBMC in less time than other methods with STEMCELLs NEW Human Treg Isolation Kits - http://www.stemcell.com/en/Products/All-Products/Complete-Kit-for-Human-CD4CD127lowCD25-Regulatory-T-Cells.aspx
- published: 23 Mar 2010
- views: 3632
44:22
Chronic Inflammation - T Regulatory Cells (Lecture 4)
- Order: Reorder
- Duration: 44:22
- Uploaded Date: 02 Jun 2022
- views: 9880
Chronic Inflammation - T Regulatory Cells (Lecture 4)
An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function....
Chronic Inflammation - T Regulatory Cells (Lecture 4)
An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function. Let's review this promising area of immunology.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special-p/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #chronicinflammation
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
A good reference diagram in the book:
FIGURE 15.6 Mechanism of action of CTLA-4. A, Cytotoxic T lymphocyte antigen 4 (CTLA-4) expressed on regulatory T cells (Tregs) or activated T cells can inhibit the activation of responding T cells on the same antigen-presenting cells (APCs) (in trans). B, CTLA-4 on regulatory or activated T cells binds to B7 molecules on APCs and removes these molecules from the surface of the APCs, making the B7 costimulators unavailable to CD28 and blocking T cell activation. This action of CTLA-4 is able to suppress immune responses best when B7 levels are low, enabling CTLA-4 to out-compete the lower-affinity receptor CD28.
References:
Textbook: Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition.
URL list from Wednesday, May. 31 2022
DrBeen: Medical Education Online
https://www.drbeen.com/
Targeting IL-2: an unexpected effect in treating immunological diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-017-0002-5#:~:text=While%20IL%2D2%20is%20generally,unwanted%20immune%20responses%20and%20eventually
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients - PubMed
https://pubmed.ncbi.nlm.nih.gov/16304057/
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473973/
IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule - PubMed
https://pubmed.ncbi.nlm.nih.gov/34305950/
Chronic Inflammation - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK493173/
Inflammation - Wikipedia
https://en.wikipedia.org/wiki/Inflammation
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753746/
Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology
https://www.frontiersin.org/articles/10.3389/fimmu.2018.01523/full
https://wn.com/Chronic_Inflammation_T_Regulatory_Cells_(Lecture_4)
Chronic Inflammation - T Regulatory Cells (Lecture 4)
An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function. Let's review this promising area of immunology.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special-p/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #chronicinflammation
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
A good reference diagram in the book:
FIGURE 15.6 Mechanism of action of CTLA-4. A, Cytotoxic T lymphocyte antigen 4 (CTLA-4) expressed on regulatory T cells (Tregs) or activated T cells can inhibit the activation of responding T cells on the same antigen-presenting cells (APCs) (in trans). B, CTLA-4 on regulatory or activated T cells binds to B7 molecules on APCs and removes these molecules from the surface of the APCs, making the B7 costimulators unavailable to CD28 and blocking T cell activation. This action of CTLA-4 is able to suppress immune responses best when B7 levels are low, enabling CTLA-4 to out-compete the lower-affinity receptor CD28.
References:
Textbook: Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition.
URL list from Wednesday, May. 31 2022
DrBeen: Medical Education Online
https://www.drbeen.com/
Targeting IL-2: an unexpected effect in treating immunological diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-017-0002-5#:~:text=While%20IL%2D2%20is%20generally,unwanted%20immune%20responses%20and%20eventually
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients - PubMed
https://pubmed.ncbi.nlm.nih.gov/16304057/
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473973/
IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule - PubMed
https://pubmed.ncbi.nlm.nih.gov/34305950/
Chronic Inflammation - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK493173/
Inflammation - Wikipedia
https://en.wikipedia.org/wiki/Inflammation
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753746/
Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology
https://www.frontiersin.org/articles/10.3389/fimmu.2018.01523/full
- published: 02 Jun 2022
- views: 9880
55:11
Role of Regulatory T Cells in Tolerance: Implication in Human Diseases
- Order: Reorder
- Duration: 55:11
- Uploaded Date: 15 Nov 2010
- views: 10072
Air date: Wednesday, March 24, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description:...
Air date: Wednesday, March 24, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: Cells with regulatory function exist within all major T and NK cell subsets. Most attention has been focused on regulatory T (Tr) cells with a CD4+ phenotype: the naturally occurring Tr (nTreg) cells and the adaptive type 1 Tr (Tr1) cells. These two subsets of Tr cells, which are developmentally and functionally distinct, cooperate in suppressing activation of the immune system and thereby in maintaining immunological homeostasis and inducing tolerance to self and foreign antigens.
nTreg cells arise from the thymus and their suppressor function is strictly dependent on high expression of the transcription factor FOXP3, whereas Tr1 cells are induced in the periphery upon chronic stimulation with antigen in the presence of IL-10, secrete high levels of IL-10 in the absence of IL-4, and suppress antigen presenting cells and effector T cells through a cytokine-dependent mechanism. In humans, the presence of Tr1 cells is associated with tolerance, whereas defects in nTreg or Tr1 cells lead to autoimmune mediated diseases or to chronic inflammation, respectively.
We and others have dedicated much effort to establish methods to isolate and expand nTreg cells or to induce antigen-specific Tr1 cells ex vivo to be used as cell therapy to promote or rebuilt tolerance. We established a protocol to selectively expand CD4+CD25+FOXP3+ T cells with suppressive activity using rapamycin. Alternatively, we showed that exogenous IL-10 or IL-10-derived from tolerogenic dendritic cells promote the in vitro induction of Tr1 cells. Moreover, we are exploring a novel approach to generate a homogeneous population of antigen-specific Tr cells using lentiviral vector mediated gene transfer.
Alternatively, to the use of ex vivo expanded/differentiated Tr cells, these cells can be induced directly in vivo. We demonstrated that a combination therapy with depleting agents (i.e. anti CD45 mAb) and rapamycin/IL-10 treatment efficiently promoted tolerance via the induction of both nTreg and Tr1 cells. In addition, we recently showed that a small molecular weight compound that specifically activates the aryl hydrocarbon receptor is able to induce tolerance through a direct or DC mediated effects on Tr cells.
These approaches represent the first step towards the definition of new therapeutic protocols aimed to suppress pathology and restore peripheral tolerance in immune-mediated diseases.
Lecture Objectives:
1. Specify the major characteristics of human nTreg and Tr1 cells.
2. Define the role for FOXP3 in different subset of human Tr cells.
3. Outline approaches used to expand/generate human Tr cells in vitro and in vivo.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Dr. Maria Grazia Roncarolo
Runtime: 00:55:11
Permanent link: http://videocast.nih.gov/launch.asp?15755
https://wn.com/Role_Of_Regulatory_T_Cells_In_Tolerance_Implication_In_Human_Diseases
Air date: Wednesday, March 24, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: Cells with regulatory function exist within all major T and NK cell subsets. Most attention has been focused on regulatory T (Tr) cells with a CD4+ phenotype: the naturally occurring Tr (nTreg) cells and the adaptive type 1 Tr (Tr1) cells. These two subsets of Tr cells, which are developmentally and functionally distinct, cooperate in suppressing activation of the immune system and thereby in maintaining immunological homeostasis and inducing tolerance to self and foreign antigens.
nTreg cells arise from the thymus and their suppressor function is strictly dependent on high expression of the transcription factor FOXP3, whereas Tr1 cells are induced in the periphery upon chronic stimulation with antigen in the presence of IL-10, secrete high levels of IL-10 in the absence of IL-4, and suppress antigen presenting cells and effector T cells through a cytokine-dependent mechanism. In humans, the presence of Tr1 cells is associated with tolerance, whereas defects in nTreg or Tr1 cells lead to autoimmune mediated diseases or to chronic inflammation, respectively.
We and others have dedicated much effort to establish methods to isolate and expand nTreg cells or to induce antigen-specific Tr1 cells ex vivo to be used as cell therapy to promote or rebuilt tolerance. We established a protocol to selectively expand CD4+CD25+FOXP3+ T cells with suppressive activity using rapamycin. Alternatively, we showed that exogenous IL-10 or IL-10-derived from tolerogenic dendritic cells promote the in vitro induction of Tr1 cells. Moreover, we are exploring a novel approach to generate a homogeneous population of antigen-specific Tr cells using lentiviral vector mediated gene transfer.
Alternatively, to the use of ex vivo expanded/differentiated Tr cells, these cells can be induced directly in vivo. We demonstrated that a combination therapy with depleting agents (i.e. anti CD45 mAb) and rapamycin/IL-10 treatment efficiently promoted tolerance via the induction of both nTreg and Tr1 cells. In addition, we recently showed that a small molecular weight compound that specifically activates the aryl hydrocarbon receptor is able to induce tolerance through a direct or DC mediated effects on Tr cells.
These approaches represent the first step towards the definition of new therapeutic protocols aimed to suppress pathology and restore peripheral tolerance in immune-mediated diseases.
Lecture Objectives:
1. Specify the major characteristics of human nTreg and Tr1 cells.
2. Define the role for FOXP3 in different subset of human Tr cells.
3. Outline approaches used to expand/generate human Tr cells in vitro and in vivo.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Dr. Maria Grazia Roncarolo
Runtime: 00:55:11
Permanent link: http://videocast.nih.gov/launch.asp?15755
- published: 15 Nov 2010
- views: 10072
PLAYLIST TIME:
PLAYLIST TIME:
9:05
Regulatory T cells
This video describes a detailed mechanism of action of regulatory T cell and also describe...
published: 30 May 2018
Regulatory T cells
Regulatory T cells
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- published: 30 May 2018
- views: 84837
This video describes a detailed mechanism of action of regulatory T cell and also describes the genetic and epigenetic basis of Treg lineage specification.
3:52
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Regulator...
published: 30 Mar 2023
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
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- published: 30 Mar 2023
- views: 14283
Roles of Regulatory T Cells | Immunology | Immune System | Basic Science Series
Regulatory T cells, Tregs, immune tolerance, autoimmune diseases, Foxp3, thymus, peripheral immune tolerance, inflammation, anti-inflammatory cytokines, IL-10, TGF-beta, cytolysis, metabolic regulation, glucose, amino acids, dendritic cells, cancer, infections, immune-mediated damage, immune system, T cell subsets, natural Tregs, induced Tregs, immune response, immune-mediated diseases, immune homeostasis, self-reactive T cells, host tissues, immune modulation, immune suppression, immune regulation.
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1:16:42
"Regulatory T cells for Immune Tolerance" by Dr. Shimon Sakaguchi
GLOBAL IMMUNOTALK 05-31-23
published: 01 Jun 2023
"Regulatory T cells for Immune Tolerance" by Dr. Shimon Sakaguchi
"Regulatory T cells for Immune Tolerance" by Dr. Shimon Sakaguchi
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- published: 01 Jun 2023
- views: 5875
GLOBAL IMMUNOTALK 05-31-23
0:24
Regulatory T Cells - Wallchart
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published: 07 May 2020
Regulatory T Cells - Wallchart
Regulatory T Cells - Wallchart
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- published: 07 May 2020
- views: 440
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4:08
Brandl's Basics: T regulatory cells
This video explains the differentiation of T regulatory cells from CD4 positive T cells.
published: 04 May 2020
Brandl's Basics: T regulatory cells
Brandl's Basics: T regulatory cells
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- published: 04 May 2020
- views: 5886
This video explains the differentiation of T regulatory cells from CD4 positive T cells.
9:59
What does a regulatory T cell (Treg) do?
Learning objectives:
Explain the anti-inflammatory cytokine producing role of the Treg cel...
published: 11 Apr 2021
What does a regulatory T cell (Treg) do?
What does a regulatory T cell (Treg) do?
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- published: 11 Apr 2021
- views: 6922
Learning objectives:
Explain the anti-inflammatory cytokine producing role of the Treg cell.
Describe the role of TGFβ in the Treg response and how this is a good example of a positive feedback signaling loop (common in immune responses).
Explain the function of the IL-10 cytokine.
Describe the cell lysis function of Treg cells.
Explain how Tregs lyse other immune cells.
Explain how this lysis function helps to avoid allergic and autoimmune responses.
Describe how Tregs can reduce IL-2 signaling to limit immune cell proliferation.
Explain the role of Tregs in preventing and causing disease.
3:43
T-Regulatory Cells In Tumor Progression And Therapy- Video Abstract ID 228887
Video abstract of review paper “T-Regulatory Cells In Tumor Progression And Therapy&...
published: 23 Dec 2019
T-Regulatory Cells In Tumor Progression And Therapy- Video Abstract ID 228887
T-Regulatory Cells In Tumor Progression And Therapy- Video Abstract ID 228887
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- published: 23 Dec 2019
- views: 4187
Video abstract of review paper “T-Regulatory Cells In Tumor Progression And Therapy” published in the open access journal
Cancer Management and Research by Verma A, Mathur R, Farooque A, et al.
Abstract: Regulatory T cells (Tregs) are important members of the immune system regulating the host responses to infection and neoplasms. Tregs prevent autoimmune disorders by protecting the host-cells from an immune response, related to the peripheral tolerance. However, tumor cells use Tregs as a shield to protect themselves against anti-tumor immune response. Thus, Tregs are a hurdle in achieving the complete potential of anti-cancer therapies including immunotherapy. This has prompted the development of novel adjuvant therapies that obviate their negative effects thereby enhancing the therapeutic efficacy. Our earlier studies have shown the efficacy of the glycolytic inhibitor, 2-deoxy-D-glucose (2-DG) by reducing the induced Tregs pool and enhance immune stimulation as well as local tumor control. These findings have suggested its potential for enhancing the efficacy of immunotherapy, besides radiotherapy and chemotherapy. This review provides a brief account of the current status of Tregs as a component of the immune-biology of tumors and various preclinical and clinical strategies pursued to obviate the limitations imposed by them in achieving therapeutic efficacy.
Read the full paper here: https://www.dovepress.com/t-regulatory-cells-in-tumor-progression-and-therapy-peer-reviewed-article-CMAR
1:32
Treg Isolation Kits: Fast and Versatile Isolation of Human Regulatory T Cells
Get the highest purity Tregs directly from whole blood or PBMC in less time than other met...
published: 23 Mar 2010
Treg Isolation Kits: Fast and Versatile Isolation of Human Regulatory T Cells
Treg Isolation Kits: Fast and Versatile Isolation of Human Regulatory T Cells
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- published: 23 Mar 2010
- views: 3632
Get the highest purity Tregs directly from whole blood or PBMC in less time than other methods with STEMCELLs NEW Human Treg Isolation Kits - http://www.stemcell.com/en/Products/All-Products/Complete-Kit-for-Human-CD4CD127lowCD25-Regulatory-T-Cells.aspx
44:22
Chronic Inflammation - T Regulatory Cells (Lecture 4)
Chronic Inflammation - T Regulatory Cells (Lecture 4)
An important lecture in the chron...
published: 02 Jun 2022
Chronic Inflammation - T Regulatory Cells (Lecture 4)
Chronic Inflammation - T Regulatory Cells (Lecture 4)
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- published: 02 Jun 2022
- views: 9880
Chronic Inflammation - T Regulatory Cells (Lecture 4)
An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function. Let's review this promising area of immunology.
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A good reference diagram in the book:
FIGURE 15.6 Mechanism of action of CTLA-4. A, Cytotoxic T lymphocyte antigen 4 (CTLA-4) expressed on regulatory T cells (Tregs) or activated T cells can inhibit the activation of responding T cells on the same antigen-presenting cells (APCs) (in trans). B, CTLA-4 on regulatory or activated T cells binds to B7 molecules on APCs and removes these molecules from the surface of the APCs, making the B7 costimulators unavailable to CD28 and blocking T cell activation. This action of CTLA-4 is able to suppress immune responses best when B7 levels are low, enabling CTLA-4 to out-compete the lower-affinity receptor CD28.
References:
Textbook: Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition.
URL list from Wednesday, May. 31 2022
DrBeen: Medical Education Online
https://www.drbeen.com/
Targeting IL-2: an unexpected effect in treating immunological diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-017-0002-5#:~:text=While%20IL%2D2%20is%20generally,unwanted%20immune%20responses%20and%20eventually
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients - PubMed
https://pubmed.ncbi.nlm.nih.gov/16304057/
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473973/
IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule - PubMed
https://pubmed.ncbi.nlm.nih.gov/34305950/
Chronic Inflammation - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK493173/
Inflammation - Wikipedia
https://en.wikipedia.org/wiki/Inflammation
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753746/
Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology
https://www.frontiersin.org/articles/10.3389/fimmu.2018.01523/full
55:11
Role of Regulatory T Cells in Tolerance: Implication in Human Diseases
Air date: Wednesday, March 24, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washingt...
published: 15 Nov 2010
Role of Regulatory T Cells in Tolerance: Implication in Human Diseases
Role of Regulatory T Cells in Tolerance: Implication in Human Diseases
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- published: 15 Nov 2010
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Air date: Wednesday, March 24, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: Cells with regulatory function exist within all major T and NK cell subsets. Most attention has been focused on regulatory T (Tr) cells with a CD4+ phenotype: the naturally occurring Tr (nTreg) cells and the adaptive type 1 Tr (Tr1) cells. These two subsets of Tr cells, which are developmentally and functionally distinct, cooperate in suppressing activation of the immune system and thereby in maintaining immunological homeostasis and inducing tolerance to self and foreign antigens.
nTreg cells arise from the thymus and their suppressor function is strictly dependent on high expression of the transcription factor FOXP3, whereas Tr1 cells are induced in the periphery upon chronic stimulation with antigen in the presence of IL-10, secrete high levels of IL-10 in the absence of IL-4, and suppress antigen presenting cells and effector T cells through a cytokine-dependent mechanism. In humans, the presence of Tr1 cells is associated with tolerance, whereas defects in nTreg or Tr1 cells lead to autoimmune mediated diseases or to chronic inflammation, respectively.
We and others have dedicated much effort to establish methods to isolate and expand nTreg cells or to induce antigen-specific Tr1 cells ex vivo to be used as cell therapy to promote or rebuilt tolerance. We established a protocol to selectively expand CD4+CD25+FOXP3+ T cells with suppressive activity using rapamycin. Alternatively, we showed that exogenous IL-10 or IL-10-derived from tolerogenic dendritic cells promote the in vitro induction of Tr1 cells. Moreover, we are exploring a novel approach to generate a homogeneous population of antigen-specific Tr cells using lentiviral vector mediated gene transfer.
Alternatively, to the use of ex vivo expanded/differentiated Tr cells, these cells can be induced directly in vivo. We demonstrated that a combination therapy with depleting agents (i.e. anti CD45 mAb) and rapamycin/IL-10 treatment efficiently promoted tolerance via the induction of both nTreg and Tr1 cells. In addition, we recently showed that a small molecular weight compound that specifically activates the aryl hydrocarbon receptor is able to induce tolerance through a direct or DC mediated effects on Tr cells.
These approaches represent the first step towards the definition of new therapeutic protocols aimed to suppress pathology and restore peripheral tolerance in immune-mediated diseases.
Lecture Objectives:
1. Specify the major characteristics of human nTreg and Tr1 cells.
2. Define the role for FOXP3 in different subset of human Tr cells.
3. Outline approaches used to expand/generate human Tr cells in vitro and in vivo.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Dr. Maria Grazia Roncarolo
Runtime: 00:55:11
Permanent link: http://videocast.nih.gov/launch.asp?15755
Regulatory T cell
The regulatory T cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells which modulate the immune system, maintain tolerance to self-antigens, and abrogate autoimmune disease. These cells generally suppress or downregulate induction and proliferation of effector T cells. Additional regulatory T cells known as Treg17 cells have recently been identified. Mouse models have suggested that modulation of Tregs can treat autoimmune disease and cancer, and facilitate organ transplantation.
Regulatory T cell populations
T regulatory cells are a component of the immune system that suppress immune responses of other cells. This is an important "self-check" built into the immune system to prevent excessive reactions. Regulatory T cells come in many forms with the most well-understood being those that express CD4, CD25, and Foxp3 (CD4+CD25+ regulatory T cells). These "Tregs" are different from helper T cells. Another regulatory T cell subset is Treg17 cells. Regulatory T cells are involved in shutting down immune responses after they have successfully eliminated invading organisms, and also in preventing autoimmunity.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Regulatory_T_cell
Regulatory T cells...
Roles of Regulatory T Cells | Immunology | Immune ...
"Regulatory T cells for Immune Tolerance" by Dr. S...
Regulatory T Cells - Wallchart...
Brandl's Basics: T regulatory cells...
What does a regulatory T cell (Treg) do?...
T-Regulatory Cells In Tumor Progression And Therap...
Treg Isolation Kits: Fast and Versatile Isolation ...
Chronic Inflammation - T Regulatory Cells (Lecture...
Role of Regulatory T Cells in Tolerance: Implicati...
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Latest News for: tregs
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... in the Type 1 Diabetes (T1D) Treg cell therapy program.
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It highlights the strong commitment and rapid integration of our respective research teams as well as providing important early validation of our novel CAR-Treg cell therapy approach to autoimmune diseases.
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(MENAFN - PR Newswire). Treg Cell-based Therapies refer to therapeutic approaches that utilize regulatory T cells (Tregs) to modulate the immune system. Innovations in cell ... .
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Treg Cell-based Therapies Clinical Trial Pipeline Appears Robust With 51+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight
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Tröegs to commemorate Oktoberfest with 9- day celebration at Hershey-based brewery
eNewspaper. It’s like the paper, only paperless. Get a replica of the paper on your digital doorstep with eNewspaper. Lebanon Daily News ... The nine-day event will take place at the brewery between Saturday, Sept. 14 and Sunday, Sept. 22 ... to 4 p.m. Saturday.
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An integrated transcription factor framework for Treg identity and diversity
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