Acotiamide

Acotiamide
Clinical data
Routes of; administration	Oral
ATC code	none
Legal status
Legal status	Uncontrolled;
Identifiers
	IUPAC name N-{2-[Bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide;
CAS Number	185106-16-5
PubChem (CID)	5282338
ChemSpider	4445505
UNII	D42OWK5383
ChEMBL	CHEMBL2107723
Chemical and physical data
Formula	C21H30N4O5S
Molar mass	450.55 g/mol
3D model (Jmol)	Interactive image
	SMILES O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O ;
	InChI InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) ; Key:TWHZNAUBXFZMCA-UHFFFAOYSA-N ;
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Acotiamide (YM-443, Z-338) is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.^[1] It acts as an acetylcholinesterase inhibitor.

References[edit]

^ Matsueda K, Hongo M, Tack J, Aoki H, Saito Y, Kato H (January 2010). "Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage". Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 22 (6): 618–e173. doi:10.1111/j.1365-2982.2009.01449.x. PMID 20059698.

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Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	Uncontrolled
Identifiers
IUPAC name N-{2-[Bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide
CAS Number	185106-16-5^N
PubChem (CID)	5282338
ChemSpider	4445505^Y
UNII	D42OWK5383^Y
ChEMBL	CHEMBL2107723^N
Chemical and physical data
Formula	C₂₁H₃₀N₄O₅S
Molar mass	450.55 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O
InChI InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27)^Y Key:TWHZNAUBXFZMCA-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)