Aprindine
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Clinical data | |
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AHFS/Drugs.com | International Drug Names |
ATC code | C01BB04 (WHO) |
Identifiers | |
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CAS Number | 37640-71-4 ![]() |
PubChem (CID) | 2218 |
DrugBank | DB01429 ![]() |
ChemSpider | 2132 ![]() |
UNII | 5Y48085P9Q ![]() |
KEGG | D02969 ![]() |
ChEMBL | CHEMBL1213033 ![]() |
Chemical and physical data | |
Formula | C22H30N2 |
Molar mass | 322.487 g/mol |
3D model (Jmol) | Interactive image |
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Aprindine is a Class 1b antiarrhythmic agent.[1]
In one study, it delayed atrial fibrillation more than digoxin did.[2]
It has shown effectiveness when given orally.[3]
References[edit]
- ^ Sato R, Hisatome I, Tanaka Y, et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
- ^ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation". Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.[dead link]
- ^ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421
. PMID 603737.
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