Suprofen
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| Systematic (IUPAC) name | |
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(RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
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| Clinical data | |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Pregnancy category |
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| Routes of administration |
Oral, eye drops |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | 20% |
| Identifiers | |
| CAS Number | 40828-46-4  |
| ATC code | M01AE07 (WHO) |
| PubChem | CID 5359 |
| IUPHAR/BPS | 7298 |
| DrugBank | DB00870 |
| ChemSpider | 5166  |
| UNII | 988GU2F9PE |
| KEGG | D00452 |
| ChEBI | CHEBI:9362 |
| ChEMBL | CHEMBL956 |
| Chemical data | |
| Formula | C14H12O3S |
| Molar mass | 260.309 g/mol |
| 3D model (Jmol) | Interactive image |
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Suprofen is a non-steroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.
Uses[edit]
Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]
References[edit]
- ^ Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357
- ^ Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions. 24: 95–106. doi:10.1007/978-3-0348-9160-8_9. PMID 3142236.
- ^ Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
- ^ Drugs.com: suprofen ophthalmic
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