Enprostil

Enprostil

Systematic (IUPAC) name
methyl 7-[(1S,2S,3S)-3-hydroxy-2-[(3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	73121-56-9 Y
ATC code	A02BB02 (WHO)
PubChem	CID 5311225
ChemSpider	4470744
UNII	J4IP5Z9DAU Y
KEGG	D01891 Y
Chemical data
Formula	C23H28O6
Molar mass	400.46 g/mol
3D model (Jmol)	Interactive image
SMILES COC(=O)CCC=C=CC[C@@H]1[C@H]([C@@H](CC1=O)O)/C=C/[C@H](COc2ccccc2)O
InChI InChI=1S/C23H28O6/c1-28-23(27)12-8-3-2-7-11-19-20(22(26)15-21(19)25)14-13-17(24)16-29-18-9-5-4-6-10-18/h3-7,9-10,13-14,17,19-20,22,24,26H,8,11-12,15-16H2,1H3/b14-13+/t2?,17-,19-,20-,22-/m1/s1 Key:PTOJVMZPWPAXER-VFJVYMGBSA-N
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Enprostil is a synthetic prostaglandin designed to resemble dinoprostone. Enprostil was found to be a highly potent inhibitor of gastric HCl secretion.

External links

• Toshina, K.; Hirata, I.; Maemura, K.; Sasaki, S.; Murano, M.; Nitta, M.; Yamauchi, H.; Nishikawa, T.; et al. (2000). "Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines". Scandinavian Journal of Immunology. 52 (6): 570–5. doi:10.1046/j.1365-3083.2000.00815.x. PMID 11119262. 
• Tari, Akira; Hamada, Masanori; Kamiyasu, Toshiki; Sumii, Koji; Haruma, Ken; Inoue, Masaki; Kishimoto, Shinya; Kajiyama, Goro; Walsh, John H. (1997). "Effect of enprostil on omeprazole-induced hypergastrinemia and inhibition of gastric acid secretion in peptic ulcer patients". Digestive Diseases and Sciences. 42 (8): 1741–6. doi:10.1023/A:1018825902055. PMID 9286243. 
• Ching, C. K.; Lam, S. K. (1995). "A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease". Journal of Gastroenterology. 30 (5): 607–14. doi:10.1007/BF02367786. PMID 8574332.