LPAR5

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LPAR5
Identifiers
Aliases LPAR5, GPR92, GPR93, KPG_010, LPA5, lysophosphatidic acid receptor 5
External IDs MGI: 2685918 HomoloGene: 10696 GeneCards: LPAR5
Targeted by Drug
lysophosphatidic acid[1]
Orthologs
Species Human Mouse
Entrez

57121

381810
Ensembl

ENSG00000184574

ENSMUSG00000067714
UniProt

Q9H1C0

Q149R9
RefSeq (mRNA)

NM_020400
NM_001142961

NM_001163268
NM_001163269
RefSeq (protein)

NP_001136433
NP_065133

n/a
Location (UCSC) Chr 12: 6.62 – 6.64 Mb Chr 6: 125.07 – 125.08 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[4][5][6][7][8] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[9]

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Lysophosphatidic acid receptor 5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet. 26 (3): 345–8. Dec 2000. doi:10.1038/81664. PMID 11062477. 
  5. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  6. ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". J Biol Chem. 281 (33): 23589–97. doi:10.1074/jbc.M603670200. PMID 16774927. 
  7. ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther. 318 (2): 619–28. doi:10.1124/jpet.105.098848. PMID 16651401. 
  8. ^ "Entrez Gene: GPR92 G protein-coupled receptor 92". 
  9. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. 

Further reading[edit]

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 


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