GPR183

GPR183
Identifiers
Aliases	GPR183, EBI2, G protein-coupled receptor 183
External IDs	MGI: 2442034 HomoloGene: 28066 GeneCards: GPR183
Targeted by Drug
(25R)-cholest-5-ene-3β,26-diol, 7α-hydroxycholesterol
Gene ontology Molecular function • signal transducer activity • oxysterol binding • G-protein coupled receptor activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • B cell activation involved in immune response • mature B cell differentiation involved in immune response • humoral immune response • positive regulation of B cell proliferation • immune response • signal transduction • positive regulation of ERK1 and ERK2 cascade • immune system process • regulation of astrocyte chemotaxis • leukocyte chemotaxis • adaptive immune response • dendritic cell chemotaxis • T cell chemotaxis • osteoclast differentiation • dendritic cell homeostasis • cell chemotaxis • T follicular helper cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1880	321019
Ensembl	ENSG00000169508	ENSMUSG00000051212
UniProt	P32249	Q3U6B2
RefSeq (mRNA)	NM_004951	NM_183031
RefSeq (protein)	NP_004942	NP_898852.2
Location (UCSC)	Chr 13: 99.29 – 99.31 Mb	Chr 14: 121.95 – 121.97 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.

EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn off to move B cells to the germinal center from the periphery, and must turn on for B cells to exit the germinal center and re-enter the periphery. EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rosenkilde MM, Benned-Jensen T, Andersen H, et al. (2006). "Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.". J. Biol. Chem. 281 (19): 13199–208. doi:10.1074/jbc.M602245200. PMID 16540462. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.