Prostaglandin EP1 receptor

PTGER1
Identifiers
Aliases	PTGER1, EP1, EP1 receptor, prostaglandin E receptor 1
External IDs	MGI: 97793 HomoloGene: 738 GeneCards: PTGER1
Targeted by Drug
prostaglandin D2, alprostadil, dinoprostone, dinoprost, [[d:Q9254396|]], sulprostone, treprostinil, U46619
Gene ontology Molecular function • prostaglandin receptor activity • G-protein coupled receptor activity • prostaglandin E receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • response to lipopolysaccharide • signal transduction • positive regulation of cytosolic calcium ion concentration • inflammatory response • adenylate cyclase-activating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5731	19216
Ensembl	ENSG00000160951	ENSMUSG00000019464
UniProt	P34995	P35375
RefSeq (mRNA)	NM_000955	NM_013641
RefSeq (protein)	NP_000946	NP_038669.1
Location (UCSC)	Chr 19: 14.47 – 14.48 Mb	Chr 8: 83.67 – 83.67 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Prostaglandin E₂ receptor 1 (EP₁) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G_q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.

See also

• Prostaglandin E2 receptor 2 (EP2)
• Prostaglandin E2 receptor 3 (EP3)
• Prostaglandin E2 receptor 4 (EP4)
• Eicosanoid receptor

External links

• "Prostanoid Receptors: EP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166. 
• Lee TY, Watanabe Y (1975). "A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems.". Japanese heart journal. 16 (3): 243–56. doi:10.1536/ihj.16.243. PMID 1160156. 
• Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family.". Genomics. 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114. 
• Funk CD, Furci L, FitzGerald GA, et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813. 
• Kurihara Y, Endo H, Kondo H (2001). "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells.". Inflamm. Res. 50 (1): 1–5. doi:10.1007/s000110050716. PMID 11235015. 
• Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.". Mol. Vis. 8: 51–8. PMID 11951086. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Matsuoka Y, Furuyashiki T, Bito H, et al. (2003). "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–7. doi:10.1073/pnas.0633341100. PMC 153060. PMID 12642666. 
• Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.". J. Clin. Endocrinol. Metab. 88 (6): 2810–6. doi:10.1210/jc.2002-021475. PMID 12788892. 
• Kitamura T, Itoh M, Noda T, et al. (2004). "Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.". Cancer Sci. 94 (7): 618–21. doi:10.1111/j.1349-7006.2003.tb01492.x. PMID 12841871. 
• Moreland RB, Kim N, Nehra A, et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.". Int. J. Impot. Res. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138. 
• Su JL, Shih JY, Yen ML, et al. (2004). "Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.". Cancer Res. 64 (2): 554–64. doi:10.1158/0008-5472.CAN-03-1301. PMID 14744769. 
• Wu T, Wu H, Wang J, Wang J (2011). "Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain.". J Neuroinflammation. 8: 22. doi:10.1186/1742-2094-8-22. PMC 3062590. PMID 21385433. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Han C, Wu T (2005). "Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.". J. Biol. Chem. 280 (25): 24053–63. doi:10.1074/jbc.M500562200. PMID 15855163. 
• Nicola C, Timoshenko AV, Dixon SJ, et al. (2005). "EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain.". J. Clin. Endocrinol. Metab. 90 (8): 4736–46. doi:10.1210/jc.2005-0413. PMID 15886234. 
• Han C, Michalopoulos GK, Wu T (2006). "Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.". J. Cell. Physiol. 207 (1): 261–70. doi:10.1002/jcp.20560. PMID 16331686. 
• Durrenberger PF, Facer P, Casula MA, et al. (2006). "Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.". BMC neurology. 6: 1. doi:10.1186/1471-2377-6-1. PMC 1361784. PMID 16393343. 
• Zhao X, Wu T, Chang CF, et al. (2015). "Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice.". Brain Behav Immun. 46: 293–310. doi:10.1016/j.bbi.2015.02.011. PMID 25697396. 
• McGraw DW, Mihlbachler KA, Schwarb MR, et al. (2006). "Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.". J. Clin. Invest. 116 (5): 1400–9. doi:10.1172/JCI25840. PMC 1451203. PMID 16670773. 
• Horita H, Kuroda E, Hachisuga T, et al. (2007). "Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo.". Hum. Reprod. 22 (7): 1801–9. doi:10.1093/humrep/dem125. PMID 17525067. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.