AM-905

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AM-905
AM-905.svg
Identifiers
CAS Number 181139-62-8 YesY
PubChem (CID) 9998522
ChemSpider 8174103 YesY
ChEMBL CHEMBL127848 YesY
Chemical and physical data
Formula C23H34O3
Molar mass 358.513 g/mol
3D model (Jmol) Interactive image
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AM-905 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB1 and CB2 receptors.[1] It is a potent and reasonably selective agonist for the CB1 cannabinoid receptor, with a Ki of 1.2 nM at CB1 and 5.3 nM at CB2.[2]

See also[edit]

References[edit]

  1. ^ Busch-Petersen, Jakob; Hill, W. Adam; Fan, Pusheng; Khanolkar, Atmaram; Xie, Xuang-Qun; Tius, Marcus A.; Makriyannis, Alexandros (1996). "Unsaturated Side Chain β-11-Hydroxyhexahydrocannabinol Analogs". Journal of Medicinal Chemistry. 39 (19): 3790–3796. doi:10.1021/jm950934b. ISSN 0022-2623. 
  2. ^ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219