Maslinic acid
From Wikipedia, the free encyclopedia
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| Names | |
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| IUPAC name
(4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
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| Systematic IUPAC name
(2α,3β)-2,3-Dihydroxyolean-12-en-28-oic acid
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| Other names
Crategolic acid; Masilinic acid; Crataegolic acid
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| Identifiers | |
4373-41-5  |
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| 3D model (Jmol) | Interactive image |
| ChEBI | CHEBI:66682  |
| ChEMBL | ChEMBL201515 |
| ChemSpider | 66312 |
| ECHA InfoCard | 100.128.873 |
| KEGG | C16939 |
| PubChem | 73659 |
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| Properties | |
| C30H48O4 | |
| Molar mass | 472.71 g·mol−1 |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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 verify (what is ?) |
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| Infobox references | |
Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.
Pharmacology[edit]
In vitro study shows that maslinic acid inhibits serine proteases, key enzymes necessary for the spread of HIV within an individual's body.[1] It also has in vitro antiproliferative effects on colon cancer cells.[2] Maslinic acid increases EAAT2 (GLT-1) glutamate reuptake and may reduce glutamatergic toxicity in rats.[3]
References[edit]
- ^ "Compound From Olive-pomace Oil Inhibits HIV Spread". sciencedaily.com. Retrieved 2009-06-16.
- ^ Juan ME, et al. (2008). "Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells". Br J Nutr. 100 (1): 36–43. doi:10.1017/S0007114508882979. PMID 18298868.
- ^ Guan T, Qian Y, et al. (2011). "Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation". J. Neurosci. Res. 89 (11): 1829–39. doi:10.1002/jnr.22671. PMID 21800347.
