Inositol monophosphatase 2

IMPA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
Identifiers
Aliases	IMPA2
External IDs	MGI: 2149728 HomoloGene: 22799 GeneCards: IMPA2
Genetically Related Diseases
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Gene ontology Molecular function • inositol monophosphate 1-phosphatase activity • inositol monophosphate phosphatase activity • hydrolase activity • protein binding • protein homodimerization activity • magnesium ion binding • metal ion binding • inositol monophosphate 3-phosphatase activity • inositol monophosphate 4-phosphatase activity Cellular component • cytoplasm • cytosol Biological process • phosphate-containing compound metabolic process • phosphatidylinositol phosphorylation • inositol phosphate metabolic process • inositol phosphate dephosphorylation • inositol metabolic process • inositol biosynthetic process • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3613	114663
Ensembl	ENSG00000141401	ENSMUSG00000024525
UniProt	O14732	Q91UZ5
RefSeq (mRNA)	NM_014214	NM_053261
RefSeq (protein)	NP_055029.1	NP_444491.1
Location (UCSC)	Chr 18: 11.98 – 12.03 Mb	Chr 18: 67.29 – 67.32 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene. IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Yoshikawa T, Padigaru M, Karkera JD, et al. (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)". Mol. Psychiatry. 5 (2): 165–71. doi:10.1038/sj.mp.4000688. PMID 10822344. 
• Sjøholt G, Gulbrandsen AK, Løvlie R, et al. (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients". Mol. Psychiatry. 5 (2): 172–80. doi:10.1038/sj.mp.4000681. PMID 10822345. 
• Yoon IS, Li PP, Siu KP, et al. (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder". Mol. Psychiatry. 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID 11673796. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Azzouz TN, Schumperli D (2004). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA. 9 (12): 1532–41. doi:10.1261/rna.5143303. PMC 1370506. PMID 14624008. 
• Sjøholt G, Ebstein RP, Lie RT, et al. (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry. 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID 14699425. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Nakayama J, Yamamoto N, Hamano K, et al. (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18". Neurology. 63 (10): 1803–7. doi:10.1212/01.wnl.0000144499.34164.e0. PMID 15557493. 
• Ohnishi T, Ohba H, Seo KC, et al. (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342. 
• Ohnishi T, Yamada K, Ohba H, et al. (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription". Neuropsychopharmacology. 32 (8): 1727–37. doi:10.1038/sj.npp.1301307. PMID 17251911. 
• Arai R, Ito K, Ohnishi T, et al. (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures". Proteins. 67 (3): 732–42. doi:10.1002/prot.21299. PMID 17340635. 
• Blair MA, Ma S, Abou-Khalil B, Hedera P (2007). "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients". Eur. J. Neurol. 14 (4): 424–7. doi:10.1111/j.1468-1331.2007.01702.x. PMID 17388992.