PRX-03140

PRX-03140
Clinical data
ATC code	None
Identifiers
	IUPAC name 4-hydroxy-7-isopropyl-6-oxo-N-[3-(1-piperidinyl)propyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carboxamide;
CAS Number	869493-21-0
PubChem (CID)	54677674
ChemSpider	21377738
Chemical and physical data
Formula	C19H27N3O3S
Molar mass	377.501 g/mol
3D model (Jmol)	Interactive image
	SMILES CC(C)N1C(=O)\C(=C(\O)c2ccsc12)C(=O)NCCCN3CCCCC3 ;
	InChI InChI=1S/C19H27N3O3S/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24) ; Key:SCHKZZSVELPJKU-UHFFFAOYSA-N ;

PRX-03140 is a partial agonist (18% relative to 5-HT^[1]) of the 5-HT₄ receptor that is being developed by EPIX Pharmaceuticals for Alzheimer's disease.^[2]

References[edit]

^ Shen F, Smith JA, Chang R, et al. (2011). "5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment". Neuropharmacology. 61 (1-2): 69–79. doi:10.1016/j.neuropharm.2011.02.026. PMID 21392515.
^ Shen, F (August 2011). "5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.". Neuropharmacology. 61 (1-2): 69–79. doi:10.1016/j.neuropharm.2011.02.026. PMID 21392515.

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[pmid21392515-1] Shen F, Smith JA, Chang R, et al. (2011). "5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment". Neuropharmacology. 61 (1-2): 69–79. doi:10.1016/j.neuropharm.2011.02.026. PMID 21392515.

[Shen-2] Shen, F (August 2011). "5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.". Neuropharmacology. 61 (1-2): 69–79. doi:10.1016/j.neuropharm.2011.02.026. PMID 21392515.

[1]

[2]

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PRX-03140

References[edit]

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