BMY-14802
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Clinical data | |
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ATC code | none |
Identifiers | |
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CAS Number | 105565-56-8 ![]() |
PubChem (CID) | 108046 |
IUPHAR/BPS | 8 |
ChemSpider | 97151 ![]() |
UNII | A5NB5G07JO ![]() |
ChEMBL | CHEMBL60859 ![]() |
Chemical and physical data | |
Formula | C18H22F2N4O |
Molar mass | 348.389 g/mol |
3D model (Jmol) | Interactive image |
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BMY-14802 is a drug with antipsychotic effects, which acts as both a sigma receptor antagonist, and a 5-HT1A agonist.[1][2][3][4]
References[edit]
- ^ Taylor DP, Eison MS, Moon SL, Schlemmer RF, Shukla UA, VanderMaelen CP, Yocca FD, Gallant DJ, Behling SH, Boissard CG (1993). "A role for sigma binding in the antipsychotic profile of BMY 14802?". NIDA Research Monograph. 133: 125–57. PMID 8232511.
- ^ Vanecek SA, Essman WD, Taylor DP, Woods JH (January 1998). "Discriminative stimulus characteristics of BMY 14802 in the pigeon". The Journal of Pharmacology and Experimental Therapeutics. 284 (1): 1–9. PMID 9435153.
- ^ Kitanaka J, Kitanaka N, Tatsuta T, Hall FS, Uhl GR, Tanaka K, Nishiyama N, Morita Y, Takemura M (May 2009). "Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice". Psychopharmacology. 203 (4): 781–92. doi:10.1007/s00213-008-1425-z. PMC 3157915
. PMID 19052726.
- ^ Paquette MA, Foley K, Brudney EG, Meshul CK, Johnson SW, Berger SP (July 2009). "The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism". Psychopharmacology. 204 (4): 743–54. doi:10.1007/s00213-009-1505-8. PMC 2845289
. PMID 19283364.
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