Chlorproethazine
From Wikipedia, the free encyclopedia
Names | |
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IUPAC name
3-(2-chlorophenothiazin-10-yl)-N,N-diethylpropan-1-amine
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Identifiers | |
84-01-5 4611-02-3 |
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3D model (Jmol) | Interactive image |
ChEMBL | ChEMBL2105938 |
ChemSpider | 59173 |
ECHA InfoCard | 100.001.373 |
KEGG | D07308 |
PubChem | 65750 65750 |
UNII | 960NX27Z07 |
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Properties | |
C19H23ClN2S | |
Molar mass | 346.91732 g/mol |
Pharmacology | |
N05AA07 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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verify (what is ?) | |
Infobox references | |
Chlorproethazine is an antipsychotic.
Synthesis[edit]
Chlorproethazine can be synthesized from a diphenylsulfide derivative. The general scheme is sufficiently flexible to permit the interchange of the order of some of the steps.
Thus alkylation of aniline thioether () with 3-chloro-1-diethylaminopropane leads to the intermediate (). Ring closure as above by nucleophilic aromatic displacement leads to the antipsychotic drug chlorproethazine.[1]
References[edit]
- ^ Buisson, P.; Gailliot, P.; 1956, U.S. Patent 2,769,002
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