E-6801

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E-6801
E 6801.svg
Names
IUPAC name
(6-chloro-N-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)imidazo[2,1-b]thiazole-5-sulfonamide)
Properties
C17H18ClN5O2S2
Molar mass 423.94 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

E-6801 is a partial agonist of the 5-HT6 receptor.[1] It enhanced recognition memory and reversed the memory deficits of scopolamine in an object recognition task in a rat model.[2] The mechanism of memory enhancement is due to a combined modulation of cholinergic and glutamatergic neurotransmission.

See also[edit]

References[edit]

  1. ^ Romero, G. (August 2006). "Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways". British Journal of Pharmacology. 148 (8): 1133–43. doi:10.1038/sj.bjp.0706827. PMC 1752021Freely accessible. PMID 16865095. 
  2. ^ Kendall, I. (February 2011). "E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.". Psychopharmacology. 213 (2-3): 413–30. doi:10.1007/s00213-010-1854-3. PMID 20405281. 


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