Iproclozide
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Systematic (IUPAC) name | |
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2-(4-chlorophenoxy)-N'-isopropyl-acetohydrazide
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Clinical data | |
Routes of administration |
Oral |
Legal status | |
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Identifiers | |
CAS Number | 3544-35-2 ![]() |
ATC code | N06AF06 (WHO) |
PubChem | CID 19063 |
ChemSpider | 17998 ![]() |
UNII | 1II9D6CB3J ![]() |
KEGG | D07338 ![]() |
ChEMBL | CHEMBL91238 ![]() |
Chemical data | |
Formula | C11H15ClN2O2 |
Molar mass | 242.70 g/mol |
3D model (Jmol) | Interactive image |
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Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.[1] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.[2][3]
See also[edit]
References[edit]
- ^ Suerinck A, Suerinck E (1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de médecine de Lyon. 47 (96): 573–586. PMID 5930723.
- ^ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP (1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction.". Gastroenterology. 75 (3): 492–496. PMID 680506.
- ^ Neil Kaplowitz; Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3. ISBN 9780824708115.
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