Tetrazolylglycine
Names
IUPAC name
(RS )-Amino(1H -tetrazol-5-yl)acetic acid
Identifiers
138199-51-6 N
3D model (Jmol )
Interactive image
ChEMBL ChEMBL140784 Y
ChemSpider 112321 Y
4068
PubChem 126383
InChI=1S/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8)
Y Key: UKBRUIZWQZHXFL-UHFFFAOYSA-N
Y
InChI=1/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8)
Key: UKBRUIZWQZHXFL-UHFFFAOYAB
Properties
C 3 H 5 N 5 O 2
Molar mass 143.11 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
N verify what is Y N
Infobox references
Tetrazolylglycine (Tet-Gly , LY-285,265 ) is a potent and selective NMDA receptor agonist , stimulating the NMDA receptor with higher potency than either glutamate or NMDA .[1] convulsant and excitotoxin and is used in scientific research.[2] [3]
References [ edit ]
^ Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ (1992). "DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy". Journal of Medicinal Chemistry . 35 (24): 4608–12. doi :10.1021/jm00102a015 . PMID 1361579 . ^ Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH (1991). "D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist". European Journal of Pharmacology . 203 (2): 237–43. doi :10.1016/0014-2999(91)90719-7 . PMID 1686860 . ^ Schoepp DD, Lunn WH, Salhoff CR, McDonald JW (1994). "The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin". European Journal of Pharmacology . 270 (1): 67–72. doi :10.1016/0926-6917(94)90081-7 . PMID 8157082 .
Receptor (ligands )
AMPA
NMDA
Antagonists: Competitive antagonists: AP5 (APV) AP7 CGP-37849 CGP-39551 CGP-39653 CGP-40116 CGS-19755 CPP LY-233,053 LY-235,959 LY-274,614 MDL-100,453 Midafotel (d-CPPene) NPC-12,626 NPC-17,742 PBPD PEAQX Perzinfotel PPDA SDZ-220581 Selfotel ; Noncompetitive antagonists: ARR-15,896 Caroverine Dexanabinol FPL-12495 FR-115,427 Hodgkinsine Magnesium MDL-27,266 NPS-1506 Psychotridine Zinc ; Uncompetitive pore blockers: 2-MDP 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 4-MeO-PCP 8A-PDHQ 18-MC α-Endopsychosin Alaproclate Amantadine Aptiganel Arketamine ARL-12,495 ARL-15,896-AR ARL-16,247 Budipine Conaridine Delucemine Dexoxadrol Dextrallorphan Dieticyclidine Diphenidine Dizocilpine Ephenidine Esketamine Etoxadrol Eticyclidine Fluorolintane Gacyclidine Ibogaine Ibogamine Indantadol Ketamine Ketobemidone Lanicemine Loperamide Memantine Methadone (Levomethadone )Methorphan (Dextromethorphan Levomethorphan )Methoxetamine Methoxphenidine Milnacipran Morphanol (Dextrorphan Levorphanol )NEFA Neramexane Nitromemantine Nitrous oxide Noribogaine Norketamine Orphenadrine PCPr Pethidine (meperidine) Phencyclamine Phencyclidine Propoxyphene Remacemide Rhynchophylline Rimantadine Rolicyclidine Sabeluzole Tabernanthine Tenocyclidine Tiletamine Tramadol Xenon ; Glycine site antagonists: 4-Cl-KYN (AV-101) 5,7-DCKA 7-CKA ACC ACEA-1011 ACEA-1328 AV-101 Carisoprodol CGP-39653 CNQX DNQX Felbamate Gavestinel GV-196,771 Kynurenic acid Kynurenine L-689,560 L-701,324 Licostinel (ACEA-1021) LU-73,068 MDL-105,519 Meprobamate MRZ 2/576 PNQX ZD-9379 ; NR2B subunit antagonists: Besonprodil CERC-301 (MK-0657) CO-101,244 (PD-174,494) Eliprodil Haloperidol Ifenprodil Isoxsuprine Nylidrin Ro8-4304 Ro25-6981 Traxoprodil ; Polyamine site antagonists: Arcaine Co 101676 Diaminopropane Diethylenetriamine Huperzine A Putrescine Ro 25-6981 ; Unclassified/unsorted antagonists: Bumetanide Chloroform Cyclopropane D -αAADiethyl ether Enflurane Ethanol Flufenamic acid Flupirtine Furosemide Halothane Isoflurane Metaphit Methoxyflurane Niflumic acid Pentamidine isethionate Piretanide Toluene Transcrocetin (saffron )Trichloroethane Trichloroethanol Trichloroethylene Xylene
Kainate
mGlu1
mGlu2
mGlu3
mGlu4
mGlu5
mGlu6
mGlu7
mGlu8
Transporter (blockers )
Enzyme (inhibitors )
Others
verify (what is 
