EML4

EML4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CGC
Identifiers
Aliases	EML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4
External IDs	MGI: 1926048 HomoloGene: 56841 GeneCards: EML4
Gene ontology Molecular function • molecular function Cellular component • cytoplasm • microtubule • cytoskeleton • membrane Biological process • mitotic nuclear division • microtubule-based process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27436	78798
Ensembl	ENSG00000143924	ENSMUSG00000032624
UniProt	Q9HC35	Q3UMY5
RefSeq (mRNA)	NM_001145076 NM_019063	NM_001114361 NM_001114362 NM_001286567 NM_199466
RefSeq (protein)	NP_001138548.1 NP_061936.2	NP_001107834.1 NP_001273496.1 NP_955760.3
Location (UCSC)	Chr 2: 42.17 – 42.33 Mb	Chr 17: 83.35 – 83.48 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
• Heidebrecht HJ, Buck F, Pollmann M, et al. (2000). "Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein.". Genomics. 68 (3): 348–50. doi:10.1006/geno.2000.6301. PMID 10995578. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Pollmann M, Parwaresch R, Adam-Klages S, et al. (2006). "Human EML4, a novel member of the EMAP family, is essential for microtubule formation.". Exp. Cell Res. 312 (17): 3241–51. doi:10.1016/j.yexcr.2006.06.035. PMID 16890222. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.