IGF-1 LR3
| Clinical data | |
|---|---|
| Routes of administration |
Injection |
| ATC code | None |
| Pharmacokinetic data | |
| Biological half-life | 20–30 hours |
| Identifiers | |
| Synonyms | Long R3-IGF-1; IGF-1 Long R3 |
| CAS Number | 946870-92-4 |
| Chemical and physical data | |
| Formula | C400H625N111O115S9 |
| Molar mass | 9117.5 g/mol |
Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or as LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).[1][2] It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1).[2] The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.[1][2] As a result, it is approximately three times more potent than IGF-1,[3] and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).[4]
The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.[5]
See also[edit]
References[edit]
- ^ a b Tomas FM, Lemmey AB, Read LC, Ballard FJ (1996). "Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection". J. Endocrinol. 150 (1): 77–84. doi:10.1677/joe.0.1500077. PMID 8708565.
- ^ a b c Mohan S, Baylink DJ (2002). "IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms". J. Endocrinol. 175 (1): 19–31. doi:10.1677/joe.0.1750019. PMID 12379487.
- ^ Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ (1992). "Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats" (PDF). Biochem. J. 282 ( Pt 1): 91–7. PMC 1130894
. PMID 1371669. - ^ von der Thüsen JH, Borensztajn KS, Moimas S, van Heiningen S, Teeling P, van Berkel TJ, Biessen EA (2011). "IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype". Am. J. Pathol. 178 (2): 924–34. doi:10.1016/j.ajpath.2010.10.007. PMC 3069834. PMID 21281823.
- ^ Mario Thevis (13 December 2010). Mass Spectrometry in Sports Drug Testing: Characterization of Prohibited Substances and Doping Control Analytical Assays. John Wiley & Sons. pp. 252–. ISBN 978-1-118-03514-6.
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