Prostaglandin H2
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Identifiers | |
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42935-17-1 ![]() |
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ChEBI | CHEBI:15554 ![]() |
ChemSpider | 392800 ![]() |
4483 | |
Jmol 3D model | Interactive image |
MeSH | Prostaglandin+H2 |
PubChem | 445049 |
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Properties | |
C20H32O5 | |
Molar mass | 352.465 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme.[1]
It is acted upon by:
- Prostacyclin synthase to create prostacyclin
- Thromboxane-A synthase to create thromboxane A2 and 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) (see 12-Hydroxyheptadecatrienoic acid)
- Prostaglandin D2 synthase to create prostaglandin D2
- Prostaglandin E synthase to create prostaglandin E2
It rearranges non-enzymatically to:
- A mixture of 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) and 12-(S)-hydroxy-5Z,8Z,10E-heptadecatrienoic acid (see 12-Hydroxyheptadecatrienoic acid)
References[edit]
- ^ "The Cyclooxygenase Reaction Mechanism". ACS Publications. Retrieved 18 April 2016.
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