Allele

An allele (UK /ˈæliːl/ or US /əˈliːl/), or allel, is one of a number of alternative forms of the same gene or same genetic locus. Sometimes, different alleles can result in different observable phenotypic traits, such as different pigmentation. However, most genetic variations result in little or no observable variation.

Most multicellular organisms have two sets of chromosomes; that is, they are diploid. These chromosomes are referred to as homologous chromosomes. Diploid organisms have one copy of each gene (and, therefore, one allele) on each chromosome. If both alleles are the same, they and the organism are homozygous with respect to that gene. If the alleles are different, they and the organism are heterozygous with respect to that gene.

The word "allele" is a short form of allelomorph ("other form", a word coined by William Bateson), which was used in the early days of genetics to describe variant forms of a gene detected as different phenotypes. It derives from the Greek prefix ἀλλήλ, allel, meaning "reciprocal" or "each other", which itself is related to the Greek adjective ἄλλος (allos; cognate with Latin "alius"), meaning "other".

Don’t Drink the Kool-Aid, Clinton Is The Real Spoiler Warns Jill Stein

Edit WorldNews.com 17 Oct 2016

Article by WN.com Correspondent Dallas DarlingSources claim the reason why the Clinton campaign and Democratic Party are suddenly targeting Jill Stein as a “spoiler” is she’s not your ordinary politician. To be sure, the Green Party’s presidential nominee doesn’t have a record of doing what is politically expedient, but what is politically right for the middle- and lower-working classes ... Along with reminding listeners the former U.S....

photo: AP / Jonathan Drew

A burnt couch is shown next to campaign signs at the Orange County Republican Headquarters in Hillsborough, NC on October 16 2016.

[VIDEO]: Fire Attack Destroys North Carolina GOP Office

Edit WorldNews.com 17 Oct 2016

Federal, state and local authorities are investigating the firebombing of a local Republican Party office in North Carolina Sunday in an incident one state GOP official called an act of “political terrorism,” The Associated Press reported. A bottle filled with flammable liquid was thrown through the window of the Orange County Republican Party headquarters overnight, damaging the interior before burning out ... "It's a great gesture....

photo: AP / SANA

In this photo released by the Syrian official news agency SANA, flames and smoke raise from burning cars after two bombs exploded, at Qazaz neighborhood in Damascus, Syria, on Thursday May 10, 2012.

Conflicting Reports Of Car Bomb Explosion in Southern Damascus

Edit WorldNews.com 17 Oct 2016

There were conflicting reports out of Damascus Monday concerning a car bomb explosion in a southern district of the capital, which is home to Syria’s holiest Shiite Muslim shrine, Reuters reported.A group that monitors Syria’s civil war, the British-based Syrian Observatory For Human Rights, said the car bomb went off near a checkpoint used by the ......

photo: WN / RTayco

Pink and white tablets on a stainless steel saucer.

How Big Pharma's Money Is Affecting Our Health And Our Wallets

Edit WorldNews.com 17 Oct 2016

Turning down a prescription from your doctor might not seem like a smart decision. However, recent research revealing the influence of pharmaceutical companies on doctors in many disciplines makes it clear that your prescription may have less to do with your health and more to do with a paycheck. The below infographic, created by The Law Firm, shares how the most powerful pharmaceutical companies in the U.S ... The U.S ... ....

photo: NASA

File - Backdropped by the blackness of space and Earth's horizon, the International Space Station is featured in this image photographed by an STS-134 crew member on the space shuttle Endeavour after the station and shuttle began their post-undocking relative separation, 29 May, 2011.

Move over ISS, China inches closer to operationalise its space station

Edit Newstrack India 17 Oct 2016

Beijing, Oct 17 (IANS) With the launching of its manned spacecraft, Shenzhou-11, into orbit in a project designed to develop its ability to explore space, China on Monday came a step closer to complete its first space station by 2020 and operationalise services two years later ... They will dock with the experimental Tiangong 2 space lab and spend 30 days there, the longest stay in space by Chinese astronauts ... --IANS. gb/na/rn. ....

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Novel Human Genetics Discoveries Using PacBio Long-Read Sequencing to be Presented at ASHG Annual Meeting

Edit Stockhouse 17 Oct 2016

“Single Molecule, Real-Time (SMRT) Sequencing of Expanded Spinocerebellar Ataxia Type 10 (SCA10) Pentanucleotide Repeat Alleles Directly from Genomic DNA,” by Tetsuo Ashizawa of the Houston Methodist Research Institute Poster #1690....

Novel Human Genetics Discoveries Using PacBio Long-Read Sequencing to be Presented at ASHG Annual Meeting (Pacific Biosciences of California Inc)

Edit Public Technologies 17 Oct 2016

... and phased allele haplotypes in long contiguous PacBio single-molecule reads Interactive invited workshop on Thursday, 10/20 at 7.15 a.m. ... (SMRT) Sequencing of Expanded Spinocerebellar Ataxia Type 10 (SCA10) Pentanucleotide Repeat Alleles Directly from Genomic DNA,' by Tetsuo Ashizawa of the Houston Methodist Research Institute Poster #1690....

Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other) Report 2014-2020

Edit Nasdaq Globe Newswire 17 Oct 2016

Dublin, Oct. 17, 2016 (GLOBE NEWSWIRE) -- Research and Markets has announced the addition of the "Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other)" report to their offering. Genome editing is the process of modifying the DNA of a particular organism, by introducing breaks at specific, targeted locations in the genome ... Key Topics Covered.. 1 ... 2 ... 3 ... 4 ... 5 ... 6 ... Allele Biotechnology Applied Biological Materials, Inc ... Fax....

Myriad Will Present New Data on Its Variant Classification Program at the ASHG Annual Meeting

Edit Stockhouse 17 Oct 2016

SALT LAKE CITY, Oct. 17, 2016 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ.MYGN), a leader in molecular diagnostics and personalized medicine, today announced it will present four new studies at the American Society of Human Genetics Annual Meeting being held Oct. 18-22, 2016 in Vancouver, British Columbia ... Platform Presentations Title. PMS2CL-hybrid Alleles Containing PMS2 Sequence and Other PMS2CL-derived Large Rearrangements ... Date....

Myriad Will Present New Data on Its Variant Classification Program at the ASHG Annual Meeting (Myriad Genetics Inc)

Edit Public Technologies 17 Oct 2016

(Source. Myriad Genetics Inc). SALT LAKE CITY, Oct. 17, 2016 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (MYGN), a leader in molecular diagnostics and personalized medicine, today announced it will present four new studies at the American Society of Human Genetics Annual Meeting being held Oct ... Platform Presentations Title.PMS2CL-hybrid Alleles Containing PMS2 Sequence and Other PMS2CL-derived Large Rearrangements ... Presenter. Nanda Singh ... PT....

How a Genetic Mutation From 1 Bull Caused the Loss of Half a Million Calves Worldwide (University of California - Davis)

Edit Public Technologies 14 Oct 2016

(Source. University of California - Davis) ... Now researchers have identified the mutation responsible, enabling ranchers to test for and avoid it ... 'Our discovery of a mutation that is responsible for reduced fertility is a major step toward eliminating this harmful allele from the Holstein dairy population,' said Harris Lewin, senior author of the study and a professor in the UC Davis Department of Evolution and Ecology ... Tad S ... (noodl....

BioNano’s Next-Generation Mapping (NGM) Used to Reveal the Genome Structure of the Korean Genome

Edit Nasdaq Globe Newswire 14 Oct 2016

NGM plays important role in revealing full range of structural variations across human genomes. Highlights importance of population-specific references to advance clinically-relevant precision medicine. SAN DIEGO, Oct ... Remarkably, eight chromosomal arms are resolved into single scaffolds ... This study provides extensive investigation of novel, previously unreported and Asian-specific SVs, and reports clinically-relevant alleles ... Reference....

PhD student in Genetics receives STVM's Norval-Young Award (University of Pretoria)

Edit Public Technologies 13 Oct 2016

(Source. University of Pretoria). Back. PhD student in Genetics receives STVM's Norval-Young Award. 13 October 2016 ... The title of the study is ... Evidence of the presence of a high frequency of alleles that contribute to resistance was provided and used for the development of new strategies for effective tick control in these heavily infested areas ... Ms Robbertse obtained a BSc (Medical Sciences) and a BSc Hons (Genetics) degree from UP....

Reference Materials for Your Unique Reproducibility Needs (SeraCare Life Sciences Inc)

Edit Public Technologies 12 Oct 2016

(Source ... Orthogonal testing by digital PCR is also performed for this product to establish 'ground truth' variant calls and allele frequencies that can be used to evaluate Positive and Negative Agreement for your NGS assay ... The forty variants are offered at 10%, 7%, or 4% minor allele frequency. Additionally, a single-vial 'Tri-Level' format is available with the forty variants evenly distributed across these three allele frequencies....

Adaptimmune Provides Update on Clinical Study Evaluating its SPEAR® T-Cell Therapy Targeting NY-ESO-1 in Ovarian Cancer

Edit Nasdaq Globe Newswire 12 Oct 2016

PHILADELPHIA and OXFORD, United Kingdom, Oct ... The use of fludarabine appears to be required for expansion, response and persistence of transduced cells ... This is a Phase I/IIa, open-label study of autologous T-cells genetically engineered with an enhanced affinity NY-ESO-1 T-cell receptor in ovarian cancer patients with the HLA-A*0201, HLA-A*0205, and/or HLA-A*0206 allele and whose tumor expresses the NY-ESO-1 tumor antigen ... CONTACT ... T....

Adaptimmune Provides Update on Clinical Study Evaluating its SPEAR® T-Cell Therapy Targeting NY-ESO-1 in Ovarian Cancer (Adaptimmune Therapeutics plc)

Edit Public Technologies 12 Oct 2016

(Source. Adaptimmune Therapeutics plc). PHILADELPHIA and OXFORD, United Kingdom, Oct ... Rafael Amado, Adaptimmune's Chief Medical Officer ... This is a Phase I/IIa, open-label study of autologous T-cells genetically engineered with an enhanced affinity NY-ESO-1 T-cell receptor in ovarian cancer patients with the HLA-A*0201, HLA-A*0205, and/or HLA-A*0206 allele and whose tumor expresses the NY-ESO-1 tumor antigen ... NCT01567891) ... (215) 825-9306 E....

Culprits in genetic epilepsies October 11, 2016 (Vanderbilt University)

Edit Public Technologies 11 Oct 2016

(Source. Vanderbilt University) ... Many variations have been identified in GABRs, but molecular characterization of their contribution as susceptibility alleles for sporadic genetic epilepsies is missing. Ciria Hernandez, M.D., Ph.D., Robert Macdonald, M.D., Ph.D., and colleagues investigated the effects of 32 GABR variants on receptor function and biogenesis. They reported Sept ... (noodl....

Final Results of NAPOLI-1 Study Confirm Overall Survival and Progression-Free Survival Benefit for the ONIVYDE® Regimen for Patients with Metastatic Pancreatic Cancer (Merrimack Pharmaceuticals Inc)

Edit Public Technologies 11 Oct 2016

(Source. Merrimack Pharmaceuticals Inc). CAMBRIDGE, Mass., Oct. 11, 2016 /PRNewswire/ -- Merrimack Pharmaceuticals, Inc. (NASDAQ ... 'Pancreatic cancer is a devastating disease with a poor prognosis ... 6.2 months versus 4.2 months (p=0.039, hazard ratio (HR) =0.75, 95% CI. [.057 - .99]) ... The recommended starting dose of ONIVYDE in patients known to be homozygous for the UGT1A1*28 allele is 50 mg/m administered by IV infusion over 90 minutes....

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Don’t Drink the Kool-Aid, Clinton Is The Real Spoiler Warns Jill Stein

[VIDEO]: Fire Attack Destroys North Carolina GOP Office

Conflicting Reports Of Car Bomb Explosion in Southern Damascus

How Big Pharma's Money Is Affecting Our Health And Our Wallets

Move over ISS, China inches closer to operationalise its space station

You can search using any combination of the items listed below.

Novel Human Genetics Discoveries Using PacBio Long-Read Sequencing to be Presented at ASHG Annual Meeting

Novel Human Genetics Discoveries Using PacBio Long-Read Sequencing to be Presented at ASHG Annual Meeting (Pacific Biosciences of California Inc)

Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other) Report 2014-2020

Myriad Will Present New Data on Its Variant Classification Program at the ASHG Annual Meeting

Myriad Will Present New Data on Its Variant Classification Program at the ASHG Annual Meeting (Myriad Genetics Inc)

How a Genetic Mutation From 1 Bull Caused the Loss of Half a Million Calves Worldwide (University of California - Davis)

BioNano’s Next-Generation Mapping (NGM) Used to Reveal the Genome Structure of the Korean Genome

PhD student in Genetics receives STVM's Norval-Young Award (University of Pretoria)

Reference Materials for Your Unique Reproducibility Needs (SeraCare Life Sciences Inc)

Adaptimmune Provides Update on Clinical Study Evaluating its SPEAR® T-Cell Therapy Targeting NY-ESO-1 in Ovarian Cancer

Adaptimmune Provides Update on Clinical Study Evaluating its SPEAR® T-Cell Therapy Targeting NY-ESO-1 in Ovarian Cancer (Adaptimmune Therapeutics plc)

Culprits in genetic epilepsies October 11, 2016 (Vanderbilt University)

Final Results of NAPOLI-1 Study Confirm Overall Survival and Progression-Free Survival Benefit for the ONIVYDE® Regimen for Patients with Metastatic Pancreatic Cancer (Merrimack Pharmaceuticals Inc)