2,5-Dimethoxy-4-trifluoromethylamphetamine
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Identifiers | |
CAS Number | 159277-07-3 N 159277-12-0 (hydrochloride) |
PubChem | CID 10400521 |
ChemSpider | 8575959 Y |
ChEMBL | CHEMBL6620 Y |
Synonyms | 2,5-Dimethoxy-4-trifluoromethylamphetamine |
Chemical and physical data | |
Systematic (IUPAC) name: (RS)-1-[2,5-Dimethoxy-4-(trifluoromethyl)phenyl]propan-2-amine
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3D model (Jmol) | Interactive image |
Formula | C12H16F3NO2 |
Molar mass | 263.26 g/mol |
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2,5-Dimethoxy-4-trifluoromethylamphetamine (DOTFM) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized in 1994 by a team at Purdue University led by David E. Nichols.[1] DOTFM is the alpha-methylated analogue of 2C-TFM, and is around twice as potent in animal studies. It acts as an agonist at the 5HT2A and 5HT2C receptors.[1] In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.[1]
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Phenethylamines |
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Amphetamines |
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Phentermines |
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Cathinones |
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Phenylisobutylamines | |
Phenylalkylpyrrolidines | |
Catecholamines (and close relatives) |
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