Neurogenic locus notch homolog protein 4

Neurogenic locus notch homolog 4 also known as notch 4 is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.

Gene

An alternative splice variant of the NOTCH4 gene has been described, but its biological significance has not been determined.

Structure

The neurogenic locus notch homolog 4 protein is a member of the Notch family. Members of this type 1 transmembrane protein family share structural characteristics. These include an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain that consists of multiple, but different, domain types.

Function

Notch protein family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling pathway is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells

In Drosophilia, notch interacts with its cell-bound ligands (delta and serrate), and establishes an intercellular signaling pathway that then plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. The notch protein is cleaved in the trans-Golgi network, and then presented on the cell surface as a heterodimer. The protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal, and hepatic development.

Notch 2

Neurogenic locus notch homolog protein 2 also known as notch 2 is a protein that in humans is encoded by the NOTCH2 gene.

NOTCH2 is associated with Alagille syndrome and Hajdu–Cheney syndrome.

Function

Notch 2 is a member of the notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.

Notch 1

Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.

Function

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

Peace be upon him (Islam)

The Arabic phrase ʿalayhi as-salām (عليه السلام), which translates as "peace be upon him" is a conventionally complimentary phrase or durood attached to the names of the prophets in Islam. The English phrase is also given the abbreviation pbuh in writing. An extended variant of the phrase reads salla llāhu ʿalayhi wa-alehe wa-sallam (Arabic: صلى الله عليه وآله وسلم‎) [lit.] "prayer of God be upon him and his family and peace", and it is often abbreviated SAWS in writing in an English-language context. The Arabic phrase is given the name ṣalawāt. The phrase is encoded as a ligature at Unicode codepoint U+FDFA ﷺ ARABIC LIGATURE SALLALLAHOU ALAYHE WASALLAM

Some Islamic scholars have voiced disagreement with the practice of abbreviating these phrases, arguing that it demonstrates laziness and a lack of respect.

Variants of the phrase in Arabic

Saw (2004 film)

Saw is a 2004 American psychological thriller horror film directed by James Wan. It is Wan's feature film directorial debut. The screenplay, written by Leigh Whannell, is based on a story by Wan and Whannell. The film stars Cary Elwes and Leigh Whannell as two men who awake to find themselves chained in a large dilapidated bathroom, with one being ordered to kill the other or his family will die. It is the first installment of the seven-part Saw franchise.

The debut of Wan and Whannell, the screenplay was written in 2001, but after failed attempts to get the script produced in Wan and Whannell's home country of Australia, they were urged to travel to Los Angeles. In order to help attract producers they shot a low-budget short film of the same name from a scene out of the script. This proved successful in 2003 as producers from Evolution Entertainment were immediately attached and also formed a horror genre production label Twisted Pictures. The film was given a small budget and shot for 18 days.

Saw (disambiguation)

A saw is a cutting tool.

Saw or SAW may also refer to:

Film