Viqualine

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Viqualine
Viqualine.png
Systematic (IUPAC) name
4-[3-[(3R,4R)-3-Ethenylpiperidin-4-yl]propyl]-6-methoxyquinoline
Identifiers
CAS Number 72714-74-0 YesY
PubChem CID 3050111
ChemSpider 2312222 N
UNII 1Y3A5E2L1J YesY
ChEMBL CHEMBL2104497 N
Chemical data
Formula C20H26N2O
Molar mass 310.432 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Viqualine (INN) (developmental code name PK-5078) is an antidepressant and anxiolytic drug that was never marketed.[1][2][3] It acts as a potent and selective serotonin releasing agent and serotonin reuptake inhibitor.[3][4] In addition, viqualine displaces diazepam from the GABAA receptor and produces benzodiazepine-like effects, indicating that it is also a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.[3][5] The drug has mainly been researched as a potential treatment for alcoholism.[6][7]

See also[edit]

References[edit]

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1–. ISBN 978-1-4757-2085-3. 
  2. ^ Faravelli C, Albanesi G, Sessarego A (1988). "Viqualine in resistant depression: a double-blind, placebo-controlled trial". Neuropsychobiology. 20 (2): 78–81. doi:10.1159/000118477. PMID 3075725. 
  3. ^ a b c George I. Papakostas; Maurizio Fava (2010). Pharmacotherapy for Depression and Treatment-resistant Depression. World Scientific. pp. 304–. ISBN 978-981-4287-59-3. 
  4. ^ Le Fur G, Imbault F, Mitrani N, Marquis F, Renault C, Dubroeucq MC, Gueremy C, Uzan A (February 1984). "The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives". Neuropharmacology. 23 (2A): 169–73. doi:10.1016/S0028-3908(84)80010-6. PMID 6717757. 
  5. ^ Faravelli, Carlo; Albanesi, Giorgio; Sessarego, Antonella (1988). "Viqualine in Resistant Depression: A Double-Blind, Placebo-Controlled Trial". Neuropsychobiology. 20 (2): 78–81. doi:10.1159/000118477. ISSN 1423-0224. 
  6. ^ Naranjo CA, Sellers EM (1989). "Serotonin uptake inhibitors attenuate ethanol intake in problem drinkers". Recent Developments in Alcoholism : an Official Publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. 7: 255–66. PMID 2522667. 
  7. ^ Naranjo CA, Sullivan JT, Kadlec KE, Woodley-Remus DV, Kennedy G, Sellers EM (September 1989). "Differential effects of viqualine on alcohol intake and other consummatory behaviors". Clinical Pharmacology and Therapeutics. 46 (3): 301–9. doi:10.1038/clpt.1989.142. PMID 2673621. 


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