Eterobarb
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| Systematic (IUPAC) name | |
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5-ethyl-1,3-bis(methoxymethyl)-5-phenyl-1,3-diazinane-2,4,6-trione
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| Clinical data | |
| Routes of administration |
Oral |
| Identifiers | |
| CAS Number | 27511-99-5  |
| ATC code | none |
| PubChem | CID 33925 |
| ChemSpider | 31271  |
| UNII | 432SI047GA |
| KEGG | D04077 |
| Chemical data | |
| Formula | C16H20N2O5 |
| Molar mass | 320.340 g/mol |
| 3D model (Jmol) | Interactive image |
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Eterobarb (Antilon) is a barbiturate derivative. It has mainly anticonvulsant action with less sedative effects than the closely related compound phenobarbital. It saw reasonable success in clinical trials, but is not in widespread medical use.[1][2]
Synthesis[edit]
Eterobarb can be synthesized by reacting phenobarbital with chloromethyl methyl ether in presence of a base.[3]
References[edit]
- ^ Gallagher, BB; Baumel, IP; Woodbury, SG; Dimicco, JA (1975). "Clinical evaluation of eterobarb, a new anticonvulsant drug". Neurology. 25 (5): 399–404. doi:10.1212/wnl.25.5.399. PMID 1094318.
- ^ Smith, DB; Goldstein, SG; Roomet, A (1986). "A comparison of the toxicity effects of the anticonvulsant eterobarb (antilon, DMMP) and phenobarbital in normal human volunteers". Epilepsia. 27 (2): 149–55. doi:10.1111/j.1528-1157.1986.tb03518.x. PMID 3956454.
- ^ Vida, Julius A. (1971). "Anticonvulsants. 1. Alkoxymethyl derivatives of barbiturates and diphenylhydantoin". Journal of Medicinal Chemistry. 14 (3): 187–189. doi:10.1021/jm00285a002.
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