Sulazepam
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
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7-Chloro-1-methyl-5-phenyl-1,3-dihydro- 2H-1,4-benzodiazepine-2-thione
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| CAS Number | 2898-13-7  |
| ATC code | none |
| PubChem | CID 17931 |
| ChemSpider | 16935 |
| UNII | NZ779Q5S0W |
| KEGG | D05942 |
| Chemical data | |
| Formula | C16H13ClN2S |
| Molar mass | 300.81 g/mol |
| 3D model (Jmol) | Interactive image |
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Sulazepam is a benzodiazepine derivative. It is the thioamide derivative of diazepam. It is metabolised into diazepam, desmethyldiazepam and oxydiazepam. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines.[1][2] It was never marketed.
Synthesis[edit]
Treatment of diazepam with phosphorus pentasulfide produces the corresponding thionamide, sulazepam.
See also[edit]
References[edit]
- ^ "sulazepam". psychotropics.dk. 2003. Retrieved 29 December 2008.
- ^ Golovenko NIa, Zin'kovskii VG (September 1976). "(title in Russian)" [Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice]. Biull Eksp Biol Med (in Russian). 82 (9): 1078–1081. PMID 11012.
- ^ Archer, G. A.; Sternbach, L. H. (1964). "Quinazolines and 1,4-Benzodiazepines. XVI.1Synthesis and Transformations of 5-Phenyl-1,4-benzodiazepine-2-thiones". The Journal of Organic Chemistry. 29: 231. doi:10.1021/jo01024a511.
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