Haloxazolam
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
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10-bromo-11b-(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
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| Clinical data | |
| Trade names | Somelin (JP) |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration |
Oral |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 59128-97-1  |
| ATC code | none |
| PubChem | CID 3563 |
| DrugBank | DB01476  |
| ChemSpider | 3442 |
| UNII | verifiedrevid = 461766568 M448L2V8XP verifiedrevid = 461766568 |
| KEGG | D01758 |
| ChEMBL | CHEMBL2104461 |
| Chemical data | |
| Formula | C17H14BrFN2O2 |
| Molar mass | 377.208 g/mol |
| 3D model (Jmol) | Interactive image |
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Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[1][2][3] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment insomnia.[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.[5]
See also[edit]
References[edit]
- ^ Tanaka, E; Terada, M; Misawa, S; Wakasugi, C (1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B. 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.
- ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Retrieved 2009-04-05.
- ^ Guan, F; Seno, H; Ishii, A; Watanabe, K; Kumazawa, T; Hattori, H; Suzuki, O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of analytical toxicology. 23 (1): 54–61. doi:10.1093/jat/23.1.54. PMID 10022210.
- ^ Tan, X; Uchida, S; Matsuura, M; Nishihara, K; Kojima, T (2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and clinical neurosciences. 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461.
- ^ Sakai, Y (1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems.". Japanese journal of pharmacology. 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.
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