Elfazepam
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
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7-Chloro-1-(2-ethylsulfonylethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
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| Identifiers | |
| CAS Number | 52042-01-0  |
| ATC code | none |
| PubChem | CID 65445 |
| ChemSpider | 58907 |
| UNII | RM53R5R2BL |
| Chemical data | |
| Formula | C19H18ClFN2O3S |
| Molar mass | 408.87 |
| 3D model (Jmol) | Interactive image |
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Elfazepam[1] is a drug which is a benzodiazepine derivative.[2] Presumably it has sedative and anxiolytic actions like those of other benzodiazepines.
It has appetite stimulating properties in animals.[3][4] The mechanism for increasing feed intake is not clear and has been subject of investigation.[5] It has been found that elfazepam suppresses gastric acid secretion.[6]
Synthesis[edit]
Benzophenone derivative 1 is reacted with a glycine equvalent masked as an oxazolidine-2,5-dione.
References[edit]
- ^ U.S. Patent 4,010,154
- ^ Psychotropics.dk
- ^ Baile, CA.; McLaughlin, CL. (Nov 1979). "A review of the behavioral and physiological responses to elfazepam, a chemical feed intake stimulant.". J Anim Sci. 49 (5): 1371–95. PMID 396294.
- ^ Baile, CA.; Naylor, J.; McLaughlin, CL.; Catanzaro, CA. (Aug 1981). "Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep.". Physiol Behav. 27 (2): 271–7. doi:10.1016/0031-9384(81)90269-9. PMID 7029576.
- ^ Keim, DA.; Baile, CA.; Bolton, JR.; Wangsness, PJ.; Della Fera, MA. (Jan 1979). "Abomasal function following injections of elfazepam and 9-aza-cannabinol.". Pharmacol Biochem Behav. 10 (1): 63–70. doi:10.1016/0091-3057(79)90170-9. PMID 35793.
- ^ Van Den Broek, GW.; Robertson, J.; Keim, DA.; Baile, CA. (Jul 1979). "Feeding and depression of abomasal secretion in sheep elicited by elfazepam and 9-aza-cannabinol.". Pharmacol Biochem Behav. 11 (1): 51–6. doi:10.1016/0091-3057(79)90296-x. PMID 493298.
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