Alanine transaminase
Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). It is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase (SGPT). ALT is found in plasma and in various body tissues, but is most common in the liver. It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.
Function
ALT catalyzes the transfer of an amino group from L-alanine to α-ketoglutarate, the products of this reversible transamination reaction being pyruvate and L-glutamate.
ALT (and all transaminases) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid.
Clinical significance
ALT is commonly measured clinically as a part of a diagnostic evaluation of hepatocellular injury, to determine liver health. When used in diagnostics, it is almost always measured in international units/liter (IU/L). While sources vary on specific reference range values for patients, 10-40 IU/L is the standard reference range for experimental studies. Alanine transaminase shows a marked diurnal variation.
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Long Gone and Moved On
by: ScriptWhen's the day you start again
And when the hell does you'll get over it begin
I'm looking hard in the mirror
But I don't fit my skin
It's too much to take
It's too hard to break me
From the cell I'm in
Oh from this moment on
I'm changing the way I feel yeah
From this moment on
It's time to get a real
Cause I still don't know how to act
Don't know what to say
Still wear the scars like it was yesterday
But you're long gone and moved on
Cause you're long gone
But I still don't know where to start, still finding my
Still talk about you like it was yesterday
But you're long gone and moved on
But you're long gone, you moved on
So how'd you pick the pieces up yeah
I'm barely used to saying me instead of us
The elephant in the room keeps scaring off the guests
It gets under my skin to see you with him
And it's not me that you're with
Oh from this moment on
I'm changing the way I feel yeah
From this moment on
It's time to get a real
The Script Long gone and moved on lyrics found on
Cause I still don't know how to act
Don't know what to say
Still wear the scars like it was yesterday
But you're long gone and moved on
Cause you're long gone
But I still don't know where to start, still finding my
Still talk about you like it was yesterday
But you're long gone and moved on
But you're long gone, you moved on
No I can't keep thinking that you're coming back
Cause I got no business knowing where you're at
And it's gonna be hard yeah
Cause I have to wanna heal yeah
And it's gonna be hard yeah
The way I feel that I have to get real
I still don't know how to act
Don't know what to say
Still wear the scars like it was yesterday
But you're long gone and moved on
But you're long gone
But I still don't know where to start, still finding my
Still talk about you like it was yesterday
But you're long gone and moved on
But you're long gone, you moved on
But you're long gone, you moved on
Eh eh, oh oh
Eh eh, oh oh