PPP3CA

PPP3CA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V
Identifiers
Aliases	PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha
External IDs	MGI: 107164 HomoloGene: 55497 GeneCards: PPP3CA
Genetically Related Diseases
anorexia nervosa
Gene ontology Molecular function • calcium ion binding • phosphoprotein phosphatase activity • protein dimerization activity • calmodulin-dependent protein phosphatase activity • protein serine/threonine phosphatase activity • metal ion binding • calmodulin binding • protein binding • drug binding • protein heterodimerization activity • enzyme binding • calcium-dependent protein serine/threonine phosphatase activity • hydrolase activity Cellular component • postsynapse • cytoplasm • cytosol • membrane • plasma membrane • calcineurin complex • nucleoplasm • Z disc • mitochondrion • sarcolemma • nucleus Biological process • multicellular organismal response to stress • negative regulation of insulin secretion • protein import into nucleus • transition between fast and slow fiber • negative regulation of chromatin binding • G1/S transition of mitotic cell cycle • response to amphetamine • protein dephosphorylation • calcineurin-NFAT signaling cascade • modulation of synaptic transmission • positive regulation of sequence-specific DNA binding transcription factor activity • response to calcium ion • Fc-epsilon receptor signaling pathway • cellular response to drug • cardiac muscle hypertrophy in response to stress • negative regulation of dendrite morphogenesis • skeletal muscle fiber development • positive regulation of cardiac muscle hypertrophy in response to stress • excitatory postsynaptic potential • positive regulation of NFAT protein import into nucleus • T cell activation • cellular response to glucose stimulus • calcium ion transport • calcium-mediated signaling • dephosphorylation • positive regulation of transcription from RNA polymerase II promoter • Wnt signaling pathway, calcium modulating pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5530	19055
Ensembl	ENSG00000138814	ENSMUSG00000028161
UniProt	Q08209	P63328
RefSeq (mRNA)	NM_001130692 NM_000944 NM_001130691	NM_001293622 NM_008913
RefSeq (protein)	NP_000935.1 NP_001124163.1 NP_001124164.1	NP_001280551.1 NP_032939.1
Location (UCSC)	Chr 4: 101.02 – 101.35 Mb	Chr 3: 136.67 – 136.94 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Protein phosphatase 3, catalytic subunit, alpha isozyme is a protein that in humans is encoded by the PPP3CA gene.

Further reading

• Crabtree, G. R. (1999). "Generic signals and specific outcomes: Signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–614. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. 
• Wang, H. G.; Pathan, N.; Ethell, I. M.; Krajewski, S.; Yamaguchi, Y.; Shibasaki, F.; McKeon, F.; Bobo, T.; Franke, T. F.; Reed, J. C. (1999). "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD". Science. 284 (5412): 339–343. doi:10.1126/science.284.5412.339. PMID 10195903. 
• Fuentes, J. J.; Genescà, L.; Kingsbury, T. J.; Cunningham, K. W.; Pérez-Riba, M.; Estivill, X.; De La Luna, S. (2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways". Human Molecular Genetics. 9 (11): 1681–1690. doi:10.1093/hmg/9.11.1681. PMID 10861295. 
• Frey, N.; Richardson, J. A.; Olson, E. N. (2000). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proceedings of the National Academy of Sciences. 97 (26): 14632–14637. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196. 
• Siddiq, A.; Miyazaki, T.; Takagishi, Y.; Kanou, Y.; Hayasaka, S.; Inouye, M.; Seo, H.; Murata, Y. (2001). "Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism". Endocrinology. 142 (5): 1752–1759. doi:10.1210/en.142.5.1752. PMID 11316738. 
• Graef, I. A.; Chen, F.; Chen, L.; Kuo, A.; Crabtree, G. R. (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–875. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183. 
• Mukerjee, N.; McGinnis, K. M.; Gnegy, M. E.; Wang, K. K. W. (2001). "Caspase-Mediated Calcineurin Activation Contributes to IL-2 Release during T Cell Activation". Biochemical and Biophysical Research Communications. 285 (5): 1192–1199. doi:10.1006/bbrc.2001.5278. PMID 11478781. 
• Volkel, H.; Scholz, M.; Link, J.; Selzle, M.; Werner, P.; Tunnemann, R.; Jung, G.; Ludolph, A. C.; Reuter, A. (2001). "Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin". FEBS Letters. 503 (2–3): 201–205. doi:10.1016/S0014-5793(01)02730-2. PMID 11513882. 
• Esau, C.; Boes, M.; Youn, H. D.; Tatterson, L.; Liu, J. O.; Chen, J. (2001). "Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells". The Journal of Experimental Medicine. 194 (10): 1449–1459. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752. 
• Frey, N.; Olson, E. N. (2002). "Calsarcin-3, a Novel Skeletal Muscle-specific Member of the Calsarcin Family, Interacts with Multiple Z-disc Proteins". Journal of Biological Chemistry. 277 (16): 13998–14004. doi:10.1074/jbc.M200712200. PMID 11842093.