LY-2940094
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| Systematic (IUPAC) name | |
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[2-[4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol
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Oral |
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| Chemical data | |
| Formula | C22H23ClF2N4O2S |
| Molar mass | 480.96 g·mol−1 |
LY-2940094 is a potent and selective nociceptin receptor antagonist which is under investigation by Eli Lilly for the treatment of major depressive disorder and alcohol dependence.[1][2] It has demonstrated proof-of-concept clinical efficacy for depression.[3] As of 2015, it is in phase II clinical trials for both of the aforementioned indications.[1][2]
See also[edit]
References[edit]
- ^ a b Dale, Elena; Bang-Andersen, Benny; Sánchez, Connie (2015). "Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs" (PDF). Biochemical Pharmacology. 95 (2): 81–97. doi:10.1016/j.bcp.2015.03.011. ISSN 0006-2952. PMID 25813654.
- ^ a b Yin, Xin; Guven, Nuri; Dietis, Nikolas (2015). "Opioids in Depression: Not Quite There Yet" (PDF). UK Journal of Pharmaceutical and Biosciences. 3 (1): 12–17.
- ^ Post A, Smart TS, Krikke-Workel J, Dawson GR, Harmer CJ, Browning M, Jackson K, Kakar R, Mohs R, Statnick M, Wafford K, McCarthy A, Barth V, Witkin JM (2015). "A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies". Neuropsychopharmacology. doi:10.1038/npp.2015.348. PMID 26585287.
External links[edit]
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