ICI-199,441
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Systematic (IUPAC) name | |
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2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide
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Identifiers | |
CAS Number | 115199-84-3 ![]() |
PubChem | CID 3082718 |
ChEMBL | CHEMBL38576 ![]() |
Chemical data | |
Formula | C21H24Cl2N2O |
Molar mass | 391.333 g/mol |
3D model (Jmol) | Interactive image |
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ICI-199,441 is a drug which acts as a potent and selective κ-opioid agonist, and has analgesic effects.[1][2] It is a biased agonist of the KOR, and is one of a relatively few KOR ligands that is G protein-biased rather than β-arrestin-biased.[1]
See also[edit]
References[edit]
- ^ Costello GF, Main BG, Barlow JJ, Carroll JA, Shaw JS (July 1988). "A novel series of potent and selective agonists at the opioid kappa-receptor". European Journal of Pharmacology. 151 (3): 475–8. doi:10.1016/0014-2999(88)90546-8. PMID 2850924.
- ^ Narita M, Kaneko C, Miyoshi K, Nagumo Y, Kuzumaki N, Nakajima M, Nanjo K, Matsuzawa K, Yamazaki M, Suzuki T (April 2006). "Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala". Neuropsychopharmacology. 31 (4): 739–50. doi:10.1038/sj.npp.1300858. PMID 16123756.
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