Tabernanthine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
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(1R,15R,17S,18S)-17-ethyl-6-methoxy-3,13-diazapentacyclo[13.3.1.0²,¹⁰.0⁴,⁹.0¹³,¹⁸]nonadeca-2(10),4(9),5,7-tetraene
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| Identifiers | |
| CAS Number | 83-94-3 |
| ATC code | none |
| PubChem | CID 6326116 |
| ChemSpider | 4885254 |
| UNII | TV52I1S16D |
| Chemical data | |
| Formula | C20H26N2O |
| Molar mass | 310.43 g/mol |
| 3D model (Jmol) | Interactive image |
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Tabernanthine is an alkaloid found in Tabernanthe iboga.[1]
It has been used in laboratory experiments to study how addiction affects the brain.[2]
Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.[3]
See also[edit]
References[edit]
- ^ "The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine - Journal of the American Chemical Society (ACS Publications)".
- ^ Levi MS, Borne RF (October 2002). "A review of chemical agents in the pharmacotherapy of addiction". Curr. Med. Chem. 9 (20): 1807–18. doi:10.2174/0929867023368980. PMID 12369879.
- ^ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.". Brain Res. 657 (1-2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.
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