Nalmexone
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Not to be confused with naltrexone.
Systematic (IUPAC) name | |
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(5α)-3,14-dihydroxy-17-(3-methyl-2-buten-1-yl)-4,5-epoxymorphinan-6-one
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Identifiers | |
CAS Number | 16676-26-9 16291-05-7 (HCl) |
ATC code | None |
PubChem | CID 5360516 |
ChemSpider | 4514525 |
Chemical data | |
Formula | C21H25NO4 |
Molar mass | 355.428 g/mol |
3D model (Jmol) | Interactive image |
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Nalmexone (INN) (code names EN-1620A, UM-592), or nalmexone hydrochloride (USAN), is a semisynthetic, opioid partial agonist or mixed agonist-antagonist with both analgesic and narcotic antagonist properties that was never marketed.[1][2][3][4] In clinical studies it was found to have comparable analgesic efficacy to morphine, though with several-fold reduced potency.[5] In addition, nalmexone's side effects, the most common of which were sleepiness and sweating, were reported to be similar to those of morphine, albeit with a noticeably higher degree of incidence.[5]
Synthesis[edit]
See also[edit]
References[edit]
- ^ Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1395. ISBN 978-0-412-46630-4. Retrieved 11 May 2012.
- ^ Casy AF, Parfitt RT (1986). Opioid Analgesics: Chemistry and Receptors. Springer. p. 55. ISBN 978-0-306-42130-3. Retrieved 11 May 2012.
- ^ Loew GH, Berkowitz DS (1978). "Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics". Journal of Medicinal Chemistry. 21 (1): 101–106. doi:10.1021/jm00199a018. PMID 73588.
- ^ Forrest WH, Shroff PF, Mahler DL (1972). "Analgesic and other effects of nalmexone in man". Clinical Pharmacology and Therapeutics. 13 (4): 520–525. PMID 4557582.
- ^ a b National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969). Bulletin, problems of drug dependence. National Academies. p. 5873. NAP:10503. Retrieved 11 May 2012. Cite uses deprecated parameter
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