N-Phenethyl-14-ethoxymetopon
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| Systematic (IUPAC) name | |
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(5α)-14-Ethoxy-3-hydroxy-5-methyl-17-(2-phenylethyl)-4,5-epoxymorphinan-6-one
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| Identifiers | |
| PubChem | CID 11049533 |
| Chemical data | |
| Formula | C27H31NO4 |
| Molar mass | 433.538 g/mol |
| 3D model (Jmol) | Interactive image |
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N-Phenethyl-14-ethoxymetopon is a drug that is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.[1]
N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.[2]
See also[edit]
- 14-Cinnamoyloxycodeinone
- 14-Phenylpropoxymetopon
- 7-PET
- MR-2096
- N-Phenethylnormorphine
- Phenomorphan
- RAM-378
- Ro4-1539
References[edit]
- ^ Ananthan, S (2006). "Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics". The AAPS Journal. 8 (1): E118–25. doi:10.1208/aapsj080114. PMC 2751430
. PMID 16584118. - ^ Lattanzi, R; Spetea, M; Schüllner, F; Rief, SB; Krassnig, R; Negri, L; Schmidhammer, H (2005). "Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities". Journal of Medicinal Chemistry. 48 (9): 3372–8. doi:10.1021/jm040894o. PMID 15857143.
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