Flurbiprofen
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
|---|---|
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(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
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| Clinical data | |
| Trade names | Ansaid, Ocufen, Strepfen |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a687005 |
| Pregnancy category |
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| Routes of administration |
Oral |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | > 99% |
| Metabolism | Hepatic (CYP2C9) |
| Biological half-life | 4.7-5.7 hours |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 5104-49-4  |
| ATC code | M01AE09 (WHO) , M02AA19 (WHO), R02AX01 (WHO), S01BC04 (WHO) |
| PubChem | CID 3394 |
| IUPHAR/BPS | 4194 |
| DrugBank | DB00712 |
| ChemSpider | 3277 |
| UNII | 5GRO578KLP |
| KEGG | D00330 |
| ChEBI | CHEBI:5130 |
| ChEMBL | CHEMBL563 |
| Synonyms | (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid |
| PDB ligand ID | FLP (PDBe, RCSB PDB) |
| Chemical data | |
| Formula | C15H13FO2 |
| Molar mass | 244.261 g/mol |
| Chirality | Racemic mixture |
| 3D model (Jmol) | Interactive image |
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| Physical data | |
| Melting point | 117 °C (243 °F) |
| (verify) | |
Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain.[1] It is generic and is marketed under brand names worldwide, including "Ansaid" and "Froben".[2]
It was derived from propionic acid by the research arm of Boots UK during the 1960s, a period which also included the discovery of ibuprofen, indometacin, diclofenac, naproxen, ketoprofen, and sulindac.[3][4][5]:34
Side effects are analogous to those of ibuprofen. As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD.[6]
References[edit]
- ^ "Lexicomp: Flurbiprofen". Lexicomp. Wolters Kluwer. Retrieved 25 September 2015.
- ^ Drugs.com Flurbiprofen listings at drugs.com Page accessed July 3, 2015
- ^ Halford, GM; Lordkipanidzé, M; Watson, SP (2012). "50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams.". Platelets. 23 (6): 415–22. doi:10.3109/09537104.2011.632032. PMID 22098129.
- ^ Rainsford KD. Fifty years since the discovery of ibuprofen. Inflammopharmacology. 2011 Dec;19(6):293-7. PMID 22120888
- ^ Janos Fischer and C. Robin Ganellin. Analogue-based Drug Discovery II. John Wiley & Sons, 2010 ISBN 9783527632121
- ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 8. ISBN 9781284057560.
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