BRL-44408
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Systematic (IUPAC) name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole
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| CAS Number | 118343-19-4  |
| PubChem (CID) | 121850 |
| IUPHAR/BPS | 525 |
| ChemSpider | 108707  |
| ChEMBL | CHEMBL216097 |
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| Formula | C13H17N3 |
| Molar mass | 215.293 g/mol |
| 3D model (Jmol) | Interactive image |
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BRL-44408 is a drug used in scientific research which acts as a selective antagonist for the α2A adrenoreceptor.[1] It has been suggested as having potential therapeutic application in the treatment of extrapyramidal side effects produced by some antipsychotic medications.[2]
References[edit]
- ^ Alberts P (January 1993). "Subtype classification of presynaptic alpha 2-adrenoceptors". General Pharmacology. 24 (1): 1–8. PMID 8387042.
- ^ Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). "Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders". Neuroscience Letters. 454 (2): 143–7. doi:10.1016/j.neulet.2009.03.001. PMID 19429072.
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