Enprostil
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Systematic (IUPAC) name | |
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methyl 7-[(1S,2S,3S)-3-hydroxy-2-[(3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate
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Clinical data | |
AHFS/Drugs.com | International Drug Names |
Identifiers | |
CAS Number | 73121-56-9 |
ATC code | A02BB02 (WHO) |
PubChem | CID 5311225 |
ChemSpider | 4470744 |
UNII | J4IP5Z9DAU |
KEGG | D01891 |
Chemical data | |
Formula | C23H28O6 |
Molar mass | 400.46 g/mol |
3D model (Jmol) | Interactive image |
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Enprostil is a synthetic prostaglandin designed to resemble dinoprostone. Enprostil was found to be a highly potent inhibitor of gastric HCl secretion.[1]
References[edit]
- ^ Roszkowski, AP; Garay, GL; Baker, S; Schuler, M; Carter, H (1986). "Gastric antisecretory and antiulcer properties of enprostil, (+/−)-11 alpha, 15 alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-9-oxoprosta-4,5,13(t)-trienoic acid methyl ester". The Journal of Pharmacology and Experimental Therapeutics. 239 (2): 382–9. PMID 3095537.
External links[edit]
- Toshina, K.; Hirata, I.; Maemura, K.; Sasaki, S.; Murano, M.; Nitta, M.; Yamauchi, H.; Nishikawa, T.; et al. (2000). "Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines". Scandinavian Journal of Immunology. 52 (6): 570–5. doi:10.1046/j.1365-3083.2000.00815.x. PMID 11119262.
- Tari, Akira; Hamada, Masanori; Kamiyasu, Toshiki; Sumii, Koji; Haruma, Ken; Inoue, Masaki; Kishimoto, Shinya; Kajiyama, Goro; Walsh, John H. (1997). "Effect of enprostil on omeprazole-induced hypergastrinemia and inhibition of gastric acid secretion in peptic ulcer patients". Digestive Diseases and Sciences. 42 (8): 1741–6. doi:10.1023/A:1018825902055. PMID 9286243.
- Ching, C. K.; Lam, S. K. (1995). "A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease". Journal of Gastroenterology. 30 (5): 607–14. doi:10.1007/BF02367786. PMID 8574332.
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